Ypsilandrosides C-G, five new spirostanol saponins from Ypsilandra thibetica

doi:10.1016/j.steroids.2009.07.001

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Ypsilandrosides C-G, five new spirostanol saponins from Ypsilandra thibetica
	Xie, Bai-Bo 1,2; Liu, Hai-Yang1 ; Ni, Wei 1; Chen, Chang-Xiang1
刊名	STEROIDS
	2009-11-04
卷号	74 期号:12 页码:950-955
关键词	Ypsilandra Thibetica Liliaceae Spirostanol Saponins Ypsilandrosides C-g Cytotoxicity Antifungal Activity
ISSN号	0039-128X
DOI	10.1016/j.steroids.2009.07.001
文献子类	Article
英文摘要	A further phytochemical investigation on the whole plants of Ypsilandra thibetica yielded one sapogenin and 12 spirostanol saponins. Five of these are new compounds, designated as ypsilandrosides C-G (2-6). Their structures were determined by detailed spectroscopic analysis, including extensive 1D and 2D NMR data, and by the result of a hydrolytic reaction. Compounds 2-5 were rare steroidal saponins that an apiofuranosyl unit was directly linked at C-3 of the aglycone. Selected spirostanol saponins (2-6, 9) were tested for their cytotoxic activities against K562, SPC-A-1, BGC-823, Eca-109, and AGS cell lines. Compounds 6 and 9 showed moderate inhibitory activity against all five cell lines. The antifungal properties of the new spirostanol saponins (2-6) against Candida albicans were also determined. (C) 2009 Elsevier Inc. All rights reserved.
学科主题	Biochemistry & Molecular Biology ; Endocrinology & Metabolism
WOS关键词	STEROIDAL SAPONINS ; NMR-SPECTROSCOPY
WOS研究方向	Biochemistry & Molecular Biology ; Endocrinology & Metabolism
语种	英语
WOS记录号	WOS:000270759500012
资助机构	West Light Foundation of the Chinese Academy of Sciences [2908025712W1]; State Key Laboratory of Phytochemistry and Plant Resources in West China [540806321211]; Germplasm Bank of Wild Species and CAS Innovation Program of Kunming Institute of Botany
公开日期	2012-03-21
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn:8080/handle/151853/4668]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 2.Peking Univ, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
推荐引用方式 GB/T 7714	Xie, Bai-Bo,Liu, Hai-Yang,Ni, Wei,et al. Ypsilandrosides C-G, five new spirostanol saponins from Ypsilandra thibetica[J]. STEROIDS,2009,74(12):950-955.
APA	Xie, Bai-Bo,Liu, Hai-Yang,Ni, Wei,&Chen, Chang-Xiang.(2009).Ypsilandrosides C-G, five new spirostanol saponins from Ypsilandra thibetica.STEROIDS,74(12),950-955.
MLA	Xie, Bai-Bo,et al."Ypsilandrosides C-G, five new spirostanol saponins from Ypsilandra thibetica".STEROIDS 74.12(2009):950-955.