Bi-linderone, a Highly Modified Methyl-linderone Dimer from Lindera aggregata with Activity toward Improvement of Insulin Sensitivity in Vitro

doi:10.1021/ol1007247

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Bi-linderone, a Highly Modified Methyl-linderone Dimer from Lindera aggregata with Activity toward Improvement of Insulin Sensitivity in Vitro
	Wang, Fei 1,2; Gao, Yuan 2; Zhang, Ling 1; Liu, Ji-Kai 1
刊名	ORGANIC LETTERS
	2010-05-21
卷号	12 期号:10 页码:2354-2357
关键词	Sesquiterpene Lactones Water Extract Strychnifolia Root Butanolides
ISSN号	1523-7060
DOI	10.1021/ol1007247
文献子类	Article
英文摘要	Bi-linderone (1) was isolated as racemate from the traditional Chinese medicinal plant Lindera aggregata. The structure elucidation of bi-linderone was reported on the basis of extensive analysis of NMR spectra and crystal X-ray diffraction. Bi-linderone has an unprecedented spirocyclopentenedione-containing carbon skeleton and showed significant activity against glucosamine-induced insulin resistance in HepG2 cells at a concentration of 1 mu g/mL.
学科主题	Chemistry, Organic
WOS关键词	SESQUITERPENE LACTONES ; WATER EXTRACT ; STRYCHNIFOLIA ; ROOT ; BUTANOLIDES
WOS研究方向	Chemistry
语种	英语
WOS记录号	WOS:000277531000047
资助机构	National Basic Research Program of China [2009CB522300]; National Natural Science Foundation of China [30830113]; MOST [2009ZX09501-029, 2009ZX09501-013]
公开日期	2012-03-21
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn:8080/handle/151853/4284]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 2.BioBioPha Co Ltd, Kunming 656204, Peoples R China
推荐引用方式 GB/T 7714	Wang, Fei,Gao, Yuan,Zhang, Ling,et al. Bi-linderone, a Highly Modified Methyl-linderone Dimer from Lindera aggregata with Activity toward Improvement of Insulin Sensitivity in Vitro[J]. ORGANIC LETTERS,2010,12(10):2354-2357.
APA	Wang, Fei,Gao, Yuan,Zhang, Ling,&Liu, Ji-Kai.(2010).Bi-linderone, a Highly Modified Methyl-linderone Dimer from Lindera aggregata with Activity toward Improvement of Insulin Sensitivity in Vitro.ORGANIC LETTERS,12(10),2354-2357.
MLA	Wang, Fei,et al."Bi-linderone, a Highly Modified Methyl-linderone Dimer from Lindera aggregata with Activity toward Improvement of Insulin Sensitivity in Vitro".ORGANIC LETTERS 12.10(2010):2354-2357.