Rubiyunnanins C-H, cytotoxic cyclic hexapeptides from Rubia yunnanensis inhibiting nitric oxide production and NF-kappa B activation

doi:10.1016/j.bmc.2010.10.019

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	Rubiyunnanins C-H, cytotoxic cyclic hexapeptides from Rubia yunnanensis inhibiting nitric oxide production and NF-kappa B activation
	Fan, Jun-Ting 1,2; Su, Jia 1,2; Peng, Yan-Min 2,3; Li, Yan1 ; Li, Jia 3; Zhou, Yu-Bo 3; Zeng, Guang-Zhi 1; Yan, He 1,2; Tan, Ning-Hua 1
刊名	BIOORGANIC & MEDICINAL CHEMISTRY
	2010-12-01
卷号	18 期号:23 页码:8226-8234
关键词	Rubia Yunnanensis Rubiyunnanins C-h Cyclopeptides Cytotoxicity Inhibition Of No Production Nf-kappa b Pathway Inhibitors
ISSN号	0968-0896
DOI	10.1016/j.bmc.2010.10.019
文献子类	Article
英文摘要	Six new (rubiyunnanins C-H, 1-6) and five known (7-11) cyclic hexapeptides were isolated from the roots of Rubia yunnanensis (Franch.) Diels. The structures and stereochemistry of 1-6 were established by extensive spectroscopic analyses and chemical methods. All compounds (1-11) not only exhibited cytotoxic activities against a panel of eleven cancer cell lines with IC(50) values ranging from 0.001 to 56.24 mu M, but also exerted inhibitory activities against nitric oxide (NO) production in LPS and IFN-gamma-induced RAW 264.7 murine macrophages with IC(50) values ranging from 0.05 to 12.68 mu M. Furthermore, this is the first time it is being reported that compounds 2 and 7-10 significantly inhibited TNF-alpha-induced NF-kappa B activation in HEK-293-NF-kappa B luciferase stable cells with IC(50) values of 35.07, 0.03, 1.69, 12.64 and 1.18 mu M, respectively. (C) 2010 Elsevier Ltd. All rights reserved.
学科主题	Biochemistry & Molecular Biology ; Chemistry, Medicinal ; Chemistry, Organic
WOS关键词	ANTITUMOR BICYCLIC HEXAPEPTIDES ; RA-VII ; BOUVARDIA-TERNIFOLIA ; PLANT CYCLOPEPTIDES ; PROTEIN-SYNTHESIS ; CORDIFOLIA L ; CONSTITUENTS ; RADIX ; TRITERPENOIDS ; CELLS
WOS研究方向	Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry
语种	英语
WOS记录号	WOS:000284059500011
资助机构	National Natural Science Foundation of China [30725048]; National Basic Research Program of China [2009 CB522300]; Chinese Academy of Sciences [KSCX2-YW-R-177]; Science and Technology Department of Yunnan Province [2008OC011]; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences
公开日期	2012-03-21
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn:8080/handle/151853/4158]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screen, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Fan, Jun-Ting,Su, Jia,Peng, Yan-Min,et al. Rubiyunnanins C-H, cytotoxic cyclic hexapeptides from Rubia yunnanensis inhibiting nitric oxide production and NF-kappa B activation[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2010,18(23):8226-8234.
APA	Fan, Jun-Ting.,Su, Jia.,Peng, Yan-Min.,Li, Yan.,Li, Jia.,...&Tan, Ning-Hua.(2010).Rubiyunnanins C-H, cytotoxic cyclic hexapeptides from Rubia yunnanensis inhibiting nitric oxide production and NF-kappa B activation.BIOORGANIC & MEDICINAL CHEMISTRY,18(23),8226-8234.
MLA	Fan, Jun-Ting,et al."Rubiyunnanins C-H, cytotoxic cyclic hexapeptides from Rubia yunnanensis inhibiting nitric oxide production and NF-kappa B activation".BIOORGANIC & MEDICINAL CHEMISTRY 18.23(2010):8226-8234.