Albaconol, a plant-derived small molecule, inhibits macrophage function by suppressing NF-kappa B activation and enhancing SOCS1 expression

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Albaconol, a plant-derived small molecule, inhibits macrophage function by suppressing NF-kappa B activation and enhancing SOCS1 expression
	Liu, Qiuyan 1,2; Shu, Xiaoli 3; Wang, Li 3; Sun, Anna ; Liu, Jikai 4; Cao, Xuetao 1,2,3
刊名	CELLULAR & MOLECULAR IMMUNOLOGY
	2008-08-01
卷号	5 期号:4 页码:271-278
关键词	Immunosuppressant Macrophage Proinflammatory Cytokine Nf-kappa b Socs1
ISSN号	1672-7681
文献子类	Article
英文摘要	Discovery and functional identification of plant-derived small compounds as the immunosuppressant attract much attention these years. Albaconol is a new kind of small compound, prenylated resorcinol, isolated from the fruiting bodies of the inedible mushroom Albatrellus confluens. Our previous studies showed that albaconol can inhibit tumor cell growth and dendritic cell maturation. However, the immunomodulatory roles and the underlying mechanisms of albaconol have not been fully understood. In this study we investigated the effects of albaconol on the proliferation and LPS-induced proinflammatory cytokine production of macrophages. Albaconol, when used at a dose higher than 1.0 mu g/ml, inhibited proliferation of RAW264.7 cells in a dose- and time-dependent manner, and could induce cellular apoptosis when used at high dosage (>= 7.5 mu g/ml). Furthermore, we found that albaconol used at a lower dosage without apoptosis induction could significantly inhibit LPS-induced TNF-alpha, IL-6, IL-1 beta and NO production in RAW264.7 cells. The inhibition of NF-kappa B activation and enhancement of SOCS1 expression in LPS-stimulated macrophages by albaconol may contribute to the above immunosuppressive or anti-inflammatory activities of albaconol. Our results suggest that albaconol may be a potential immunosuppressive and anti-inflammatory drug.
学科主题	Immunology
WOS关键词	ALBATRELLUS-CONFLUENS ; DENDRITIC CELLS ; CYTOKINE SIGNALING-1 ; NEGATIVE REGULATION ; PHOSPHORYLATION ; INFLAMMATION ; INTERFERON ; RESOLUTION ; DISCOVERY ; RESPONSES
WOS研究方向	Immunology
语种	英语
WOS记录号	WOS:000259166800004
资助机构	National Natural Science Foundation of China [30721091]; National Key Basic Research Program of China [2007CB512403]
公开日期	2011-11-24
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn:8080/handle/151853/1709]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Second Mil Med Univ, Inst Immunol, Shanghai 200433, Peoples R China 2.Second Mil Med Univ, Natl Key Lab Med Immunol, Shanghai 200433, Peoples R China 3.Zhejiang Univ, Inst Immunol, Hangzhou 310031, Zhejiang, Peoples R China 4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resourses W China, Kunming 650204, Peoples R China
推荐引用方式 GB/T 7714	Liu, Qiuyan,Shu, Xiaoli,Wang, Li,et al. Albaconol, a plant-derived small molecule, inhibits macrophage function by suppressing NF-kappa B activation and enhancing SOCS1 expression[J]. CELLULAR & MOLECULAR IMMUNOLOGY,2008,5(4):271-278.
APA	Liu, Qiuyan,Shu, Xiaoli,Wang, Li,Sun, Anna,Liu, Jikai,&Cao, Xuetao.(2008).Albaconol, a plant-derived small molecule, inhibits macrophage function by suppressing NF-kappa B activation and enhancing SOCS1 expression.CELLULAR & MOLECULAR IMMUNOLOGY,5(4),271-278.
MLA	Liu, Qiuyan,et al."Albaconol, a plant-derived small molecule, inhibits macrophage function by suppressing NF-kappa B activation and enhancing SOCS1 expression".CELLULAR & MOLECULAR IMMUNOLOGY 5.4(2008):271-278.