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	Formal Synthesis of Aspidospermidine via the Intramolecular Cascade Transannular Cyclization
	Huang, Jiu-Zhong1,2; Jie, Xiao-Ke1,3; Wei, Kun1; Zhang, Hongbin2; Wang, Min-Cai3; Yang, Yu-Rong1
刊名	SYNLETT
	2013-06-01
卷号	24期号:10页码:1303-1306
关键词	Alkaloid Total Synthesis Palladium Cross-coupling Cyclization
ISSN号	0936-5214
通讯作者	Yang, YR (reprint author), Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Peoples R China. ; yangyurong@mail.kib.ac.cn
文献子类	Article
英文摘要	A formal synthesis of aspidospermidine is reported through a novel preparation of Stork's penultimate tricyclic ketone intermediate. The key steps of the synthesis consist of an intramolecular cascade transannular cyclization, triggered by the removal of Boc group, which simultaneously forms the C, D, and E rings of aspidospermidine and conveniently setting up the quaternary stereo-center via decarboxylative alkylation reaction of the beta-keto ester.
学科主题	Chemistry, Organic
WOS关键词	CROSS-COUPLING REACTION ; COLLECTIVE SYNTHESIS ; HELQUIST ANNULATION ; DL-QUEBRACHAMINE ; NATURAL-PRODUCTS ; SCHMIDT REACTION ; ALKALOIDS ; (+/-)-ASPIDOSPERMIDINE ; (+)-ASPIDOSPERMIDINE ; (-)-LYCOJAPODINE
WOS研究方向	Chemistry
语种	英语
WOS记录号	WOS:000320576300028
资助机构	National Natural Science of China [81102348, 21072200]; Chinese Academy of Sciences
公开日期	2013-10-16
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn:8080/handle/151853/16779]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Peoples R China 2.Yunnan Univ, Key Lab Med Chem Nat Resource, Kunming 650091, Peoples R China 3.Zhengzhou Univ, Dept Chem, Zhengzhou 450052, Peoples R China
推荐引用方式 GB/T 7714	Huang, Jiu-Zhong,Jie, Xiao-Ke,Wei, Kun,et al. Formal Synthesis of Aspidospermidine via the Intramolecular Cascade Transannular Cyclization[J]. SYNLETT,2013,24(10):1303-1306.
APA	Huang, Jiu-Zhong,Jie, Xiao-Ke,Wei, Kun,Zhang, Hongbin,Wang, Min-Cai,&Yang, Yu-Rong.(2013).Formal Synthesis of Aspidospermidine via the Intramolecular Cascade Transannular Cyclization.SYNLETT,24(10),1303-1306.
MLA	Huang, Jiu-Zhong,et al."Formal Synthesis of Aspidospermidine via the Intramolecular Cascade Transannular Cyclization".SYNLETT 24.10(2013):1303-1306.

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