Xanthones with Anti-Hepatitis B Virus Activity from Swertia mussotii

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Xanthones with Anti-Hepatitis B Virus Activity from Swertia mussotii
	Cao, Tuan-Wu 1,3; Geng, Chang-An1 ; Ma, Yun-Bao 1; He, Kang 1; Wang, Hong-Ling 1,3; Zhou, Ning-Jia 1,3; Zhang, Xue-Mei1 ; Tao, Yan-Duo 2; Chen, Ji-Jun1
刊名	PLANTA MEDICA
	2013-05-01
卷号	79 期号:8 页码:697-700
关键词	Swertia Mussotii Gentianaceae Xanthones Anti-hbv Activity
ISSN号	0032-0943
通讯作者	Chen,JJ (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, 132 Lanhei Rd, Kunming 650201, Peoples R China.
文献子类	Article
英文摘要	Two new xanthones, 8-O-beta-D-glucopyranosyl-1-hydroxy-2,3,5-trimethoxyxanthone (1) and 8-O-[beta-D-xylopyranosyl-(1 -> 6)-beta-D-glucopyranosyl]-1-hydroxy-2,3,5-trimethoxyxanthone (2), along with eighteen known xanthones (3-20) were isolated from Swertia mussotii. Their structures were elucidated on the basis of extensive spectroscopic analyses (1D- and 2D-NMR, HRESIMS, UV, IR, [alpha](D)). All compounds were evaluated for their anti-hepatitis B virus activities on HepG 2.2.15 cells line in vitro, and compounds 3-10 exhibited significant activity inhibiting hepatitis B virus DNA replication with IC50 values from 0.01 mM to 0.13 mM. Compounds 3-5 showed remarkable activity with IC50 values of 0.77, >0.98, and 0.21 mM for HBsAg, and <0.62, 0.35, and 0.04 mM for HBeAg, respectively. Meanwhile, the effects of different substitutions on the anti-hepatitis B virus activity of xanthones from S. mussotii were discussed.
学科主题	Plant Sciences ; Medicinal ; Chemistry ; Pharmacology & Pharmacy
WOS关键词	GLYCOSIDES
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy
语种	英语
WOS记录号	WOS:000319466800015
资助机构	National Science Foundation of China for Distinguished Young Scholars [81025023]; International Foundation for Science [F/5202-1]; National Natural Science Foundation of China; Yunnan Province [U0832603]; West Light Foundation of the Chinese Academy of Sciences
公开日期	2013-07-24
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn:8080/handle/151853/16529]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Chinese Acad Sci, Northwest Inst Plateau Biol, Res Ctr Biol Resources Qinghai Tibet Plateau, Xining, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Cao, Tuan-Wu,Geng, Chang-An,Ma, Yun-Bao,et al. Xanthones with Anti-Hepatitis B Virus Activity from Swertia mussotii[J]. PLANTA MEDICA,2013,79(8):697-700.
APA	Cao, Tuan-Wu.,Geng, Chang-An.,Ma, Yun-Bao.,He, Kang.,Wang, Hong-Ling.,...&Chen, Ji-Jun.(2013).Xanthones with Anti-Hepatitis B Virus Activity from Swertia mussotii.PLANTA MEDICA,79(8),697-700.
MLA	Cao, Tuan-Wu,et al."Xanthones with Anti-Hepatitis B Virus Activity from Swertia mussotii".PLANTA MEDICA 79.8(2013):697-700.