Concentricolide, an anti-HIV agent from the ascomycete Daldinia concentrica | |
Qin, XD; Dong, ZJ; Liu, JK; Yang, LM; Wang, RR; Zheng, YT; Lu, Y; Wu, YS; Zheng, QT | |
刊名 | HELVETICA CHIMICA ACTA |
2006 | |
卷号 | 89期号:1页码:127-133 |
关键词 | Fruiting Bodies Fungus Derivatives |
ISSN号 | 0018-019X |
文献子类 | Article |
英文摘要 | A novel benzofuran lactone, named concentricolide (=rel-(6R)-6-ethylbenzo[2.1-b:3,4-c']difuran-8(6H)-one; 1), was isolated along with four known compounds (friedelin, cytochalasin L-696.474, armillaramide, and russulamide) from the fruiting bodies of the xylariaceous ascomycete Daldinia concentrica. The structure of I was established by spectroscopic methods and X-ray crystallographic analysis. Its anti-HIV-1 activity was tested. Results showed that 1 inhibited HIV-1 induced cytopathic effects. The EC50 value was 0.31 mu g/ml. The therapeutic index (TI) was 247. Concentricolide exhibited the blockage (EC50 0.83 mu g/ml) on syncytium formation between HIV-1 infected cells and normal cells. |
学科主题 | Chemistry ; Multidisciplinary |
WOS关键词 | FRUITING BODIES ; FUNGUS ; DERIVATIVES |
WOS研究方向 | Chemistry |
语种 | 英语 |
WOS记录号 | WOS:000234988100014 |
公开日期 | 2011-11-24 |
内容类型 | 期刊论文 |
源URL | [http://ir.kib.ac.cn:8080/handle/151853/1609] |
专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
作者单位 | 1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China 2.Chinese Acad Sci, Kunming Inst Zool, Kunming 650223, Peoples R China 3.Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China |
推荐引用方式 GB/T 7714 | Qin, XD,Dong, ZJ,Liu, JK,et al. Concentricolide, an anti-HIV agent from the ascomycete Daldinia concentrica[J]. HELVETICA CHIMICA ACTA,2006,89(1):127-133. |
APA | Qin, XD.,Dong, ZJ.,Liu, JK.,Yang, LM.,Wang, RR.,...&Zheng, QT.(2006).Concentricolide, an anti-HIV agent from the ascomycete Daldinia concentrica.HELVETICA CHIMICA ACTA,89(1),127-133. |
MLA | Qin, XD,et al."Concentricolide, an anti-HIV agent from the ascomycete Daldinia concentrica".HELVETICA CHIMICA ACTA 89.1(2006):127-133. |
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