Gentiocrucines A-E, Five Unusual Lactonic Enamino Ketones from Swertia macrosperma and Swertia angustifolia

doi:10.1055/s-0032-1315392

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Gentiocrucines A-E, Five Unusual Lactonic Enamino Ketones from Swertia macrosperma and Swertia angustifolia
	Wang, Hong-Ling 1,2; He, Kang 1,2; Geng, Chang-An1 ; Zhang, Xue-Mei 1; Ma, Yun-Bao 1; Luo, Jie 1; Chen, Ji-Jun1
刊名	PLANTA MEDICA
	2012-11-01
卷号	78 期号:17 页码:1867-1872
关键词	Gentiocrucines A-e Swertia Macrosperma Swertia Angustifolia Gentianaceae Lactonic Enamino Ketones Anti-hbv Activity
ISSN号	0032-0943
DOI	10.1055/s-0032-1315392
通讯作者	Chen,JJ (reprint author), Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, 132 Lanhei Rd, Kunming 650201, Yunnan, Peoples R China.,chenjj@mail.kib.ac.cn
文献子类	Article
英文摘要	Five unusual lactonic enamino ketones, gentiocrucines A-E (1-5), were isolated from Swertia macrosperma and S. angustifolia. Their structures were determined based on extensive spectroscopic analyses (IR, UV, MS, 1D- and 2D-NMR). By anti-HBV assay on the HepG 2.2.15 cell line in vitro, compound 1 inhibited both the secretion of hepatitis B virus surface antigen (HBsAg) and hepatitis B virus e antigen (HBeAg) with IC50 values of 3.14 and 3.35 mM, and compound 5 only inhibited the secretion of HBsAg with an IC50 value of 2.07 mM.
学科主题	Plant Sciences ; Medicinal ; Chemistry ; Pharmacology & Pharmacy
WOS关键词	BUCH-HAM
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy
语种	英语
WOS记录号	WOS:000311718900011
资助机构	Natural National Science Foundation of China for Distinguished Young Scholars [81025023] ; National Natural Science Foundation of Yunnan Province [U0832603] ; National Natural Science Foundation of China [U0832603] ; West Light Foundation of the Chinese Academy of Sciences ; Freedom Project State Key Laboratory of Phytochemistry and Plant Resources in West China [P2010-ZZ08]
公开日期	2013-01-22
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn:8080/handle/151853/15918]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Wang, Hong-Ling,He, Kang,Geng, Chang-An,et al. Gentiocrucines A-E, Five Unusual Lactonic Enamino Ketones from Swertia macrosperma and Swertia angustifolia[J]. PLANTA MEDICA,2012,78(17):1867-1872.
APA	Wang, Hong-Ling.,He, Kang.,Geng, Chang-An.,Zhang, Xue-Mei.,Ma, Yun-Bao.,...&Chen, Ji-Jun.(2012).Gentiocrucines A-E, Five Unusual Lactonic Enamino Ketones from Swertia macrosperma and Swertia angustifolia.PLANTA MEDICA,78(17),1867-1872.
MLA	Wang, Hong-Ling,et al."Gentiocrucines A-E, Five Unusual Lactonic Enamino Ketones from Swertia macrosperma and Swertia angustifolia".PLANTA MEDICA 78.17(2012):1867-1872.