Anticancer and antiradical scavenging activity of Ageratum conyzoides L. (Asteraceae)

doi:10.4103/0973-1296.59968

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Anticancer and antiradical scavenging activity of Ageratum conyzoides L. (Asteraceae)
	Adebayo, A. H.1,2; Tan, N. H.1; Akindahunsi, A. A.3; Zeng, G. Z.1; Zhang, Y. M.1
刊名	PHARMACOGNOSY MAGAZINE
	2010
卷号	6 期号:21 页码:62-66
关键词	Ageratum Conyzoides Anticancer Antiradical Scavenging Activity Cytotoxicity
DOI	10.4103/0973-1296.59968
文献子类	Article
英文摘要	Ageratum conyzoides has been used in folklore for the treatment of a wide range of diseases. In the present investigation, the in vitro activity of ethanol, petroleum ether, ethylacetate, butanol, and water extracts of A. conyzoides were screened in some cancer cell lines using the sulphorhodamine B (SRB) assay. These cell lines include: Human non-small cell lung carcinoma (A-549), human colon adenocarcinoma (HT-29), human gastric carcinoma (SGC-7901), human golima (U-251), human breast carcinoma (MDA-MB-231), human prostate carcinoma (DU-145), human hepatic carcinoma (BEL-7402), and mouse leukemia (P-388) cancer cell lines. Furthermore, kaempferol was isolated from the ethylacetate extract and the structure was elucidated by nuclear magnetic resonance (NMR) and mass spectroscopy. The effect of DPPH antiradical activity on the extracts and kaempferol was also determined. The results showed that ethylacetate extract exhibited the highest cytotoxic activity on A-549 and P-388 cancer cells with IC(50) values of 0.68 and 0.0003 mu g/ml, respectively. Kaempferol isolated from the ethylacetate extract of A. conyzoides rapidly scavenged DPPH at a concentration of 130.07 +/- 17.36 g/kg. The result therefore showed that A. conyzoides possessed anticancer and antiradical properties.
学科主题	Chemistry, Medicinal
WOS关键词	INHIBITORS ; DISCOVERY ; APOPTOSIS ; PLANTS ; CELLS
WOS研究方向	Pharmacology & Pharmacy
语种	英语
WOS记录号	WOS:000276883000011
公开日期	2012-07-25
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn:8080/handle/151853/14471]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China 2.Covenant Univ, Coll Sci & Technol, Dept Biol Sci, Ota, Ogun State, Nigeria 3.Fed Univ Technol Akure, Dept Biochem, Akure, Nigeria
推荐引用方式 GB/T 7714	Adebayo, A. H.,Tan, N. H.,Akindahunsi, A. A.,et al. Anticancer and antiradical scavenging activity of Ageratum conyzoides L. (Asteraceae)[J]. PHARMACOGNOSY MAGAZINE,2010,6(21):62-66.
APA	Adebayo, A. H.,Tan, N. H.,Akindahunsi, A. A.,Zeng, G. Z.,&Zhang, Y. M..(2010).Anticancer and antiradical scavenging activity of Ageratum conyzoides L. (Asteraceae).PHARMACOGNOSY MAGAZINE,6(21),62-66.
MLA	Adebayo, A. H.,et al."Anticancer and antiradical scavenging activity of Ageratum conyzoides L. (Asteraceae)".PHARMACOGNOSY MAGAZINE 6.21(2010):62-66.