Nonparametric Risk and Nonparametric Odds in Quantitative Genetic Association Studies

doi:10.1038/srep12105

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	Nonparametric Risk and Nonparametric Odds in Quantitative Genetic Association Studies
	Zhang, Wei; Li, Qizhai
刊名	SCIENTIFIC REPORTS
	2015-07-15
卷号	5 页码:12
ISSN号	2045-2322
DOI	10.1038/srep12105
英文摘要	The coefficient in a linear regression model is commonly employed to evaluate the genetic effect of a single nucleotide polymorphism associated with a quantitative trait under the assumption that the trait value follows a normal distribution or is appropriately normally distributed after a certain transformation. When this assumption is violated, the distribution-free tests are preferred. In this work, we propose the nonparametric risk (NR) and nonparametric odds (NO), obtain the asymptotic normal distribution of estimated NR and then construct the confidence intervals. We also define the genetic models using NR, construct the test statistic under a given genetic model and a robust test, which are free of the genetic uncertainty. Simulation studies show that the proposed confidence intervals have satisfactory cover probabilities and the proposed test can control the type I error rates and is more powerful than the exiting ones under most of the considered scenarios. Application to gene of PTPN22 and genomic region of 6p21.33 from the Genetic Analysis Workshop 16 for association with the anticyclic citrullinated protein antibody further show their performances.
资助项目	National Science Foundation of China[11371353] ; National Science Foundation of China[61134013] ; Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences[XDB13040600]
WOS研究方向	Science & Technology - Other Topics
语种	英语
出版者	NATURE PUBLISHING GROUP
WOS记录号	WOS:000357915600002
内容类型	期刊论文
源URL	[http://ir.amss.ac.cn/handle/2S8OKBNM/20328]
专题	系统科学研究所
通讯作者	Li, Qizhai
作者单位	Chinese Acad Sci, Acad Math & Syst Sci, Key Lab Syst Control, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Wei,Li, Qizhai. Nonparametric Risk and Nonparametric Odds in Quantitative Genetic Association Studies[J]. SCIENTIFIC REPORTS,2015,5:12.
APA	Zhang, Wei,&Li, Qizhai.(2015).Nonparametric Risk and Nonparametric Odds in Quantitative Genetic Association Studies.SCIENTIFIC REPORTS,5,12.
MLA	Zhang, Wei,et al."Nonparametric Risk and Nonparametric Odds in Quantitative Genetic Association Studies".SCIENTIFIC REPORTS 5(2015):12.