Inferring transcriptional interactions and regulator activities from experimental data

	Inferring transcriptional interactions and regulator activities from experimental data
	Wang, Rui-Sheng 1,2; Zhang, Xiang-Sun 3; Chen, Luonan 1,4,5,6
刊名	MOLECULES AND CELLS
	2007-12-31
卷号	24 期号:3 页码:307-315
关键词	combinatorial regulation regulator activity transcription factor transcriptional interactions
ISSN号	1016-8478
英文摘要	Gene regulation is a fundamental process in biological systems, where transcription factors (TFs) play crucial roles. Inferring transcriptional interactions between TFs and their target genes has utmost importance for understanding the complex regulatory mechanisms in cellular systems. On one hand, with the rapid progress of various high-throughput experiment techniques, more and more biological data become available, which makes it possible to quantitatively study gene regulation in a systematic manner. On the other hand, transcription regulation is a complex biological process mediated by many events such as post-translational modifications, degradation, and competitive binding of multiple TFs. In this review, with a particular emphasis on computational methods, we report the recent advances of the research topics related to transcriptional regulatory networks, including how to infer transcriptional interactions, reveal combinatorial regulation mechanisms, and reconstruct TF activity profiles.
WOS研究方向	Biochemistry & Molecular Biology ; Cell Biology
语种	英语
出版者	KOREAN SOC MOLECULAR & CELLULAR BIOLOGY
WOS记录号	WOS:000252248000001
内容类型	期刊论文
源URL	[http://ir.amss.ac.cn/handle/2S8OKBNM/4125]
专题	中国科学院数学与系统科学研究院
通讯作者	Chen, Luonan
作者单位	1.Osaka Sangyo Univ, Dept Elect Informat & Commun Engn, Osaka 5748530, Japan 2.Renmin Univ China, Sch Informat, Beijing 100872, Peoples R China 3.CAS, Acad Math & Syst Sci, Beijing 100080, Peoples R China 4.Shanghai Univ, Inst Syst Biol, Shanghai 200444, Peoples R China 5.JST, ERATO Aihara Complex Modelling Project, Tokyo 1538530, Japan 6.Univ Tokyo, Inst Ind Sci, Tokyo 1538505, Japan
推荐引用方式 GB/T 7714	Wang, Rui-Sheng,Zhang, Xiang-Sun,Chen, Luonan. Inferring transcriptional interactions and regulator activities from experimental data[J]. MOLECULES AND CELLS,2007,24(3):307-315.
APA	Wang, Rui-Sheng,Zhang, Xiang-Sun,&Chen, Luonan.(2007).Inferring transcriptional interactions and regulator activities from experimental data.MOLECULES AND CELLS,24(3),307-315.
MLA	Wang, Rui-Sheng,et al."Inferring transcriptional interactions and regulator activities from experimental data".MOLECULES AND CELLS 24.3(2007):307-315.