Inferring transcriptional interactions and regulator activities from experimental data | |
Wang, Rui-Sheng1,2; Zhang, Xiang-Sun3; Chen, Luonan1,4,5,6 | |
刊名 | MOLECULES AND CELLS
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2007-12-31 | |
卷号 | 24期号:3页码:307-315 |
关键词 | combinatorial regulation regulator activity transcription factor transcriptional interactions |
ISSN号 | 1016-8478 |
英文摘要 | Gene regulation is a fundamental process in biological systems, where transcription factors (TFs) play crucial roles. Inferring transcriptional interactions between TFs and their target genes has utmost importance for understanding the complex regulatory mechanisms in cellular systems. On one hand, with the rapid progress of various high-throughput experiment techniques, more and more biological data become available, which makes it possible to quantitatively study gene regulation in a systematic manner. On the other hand, transcription regulation is a complex biological process mediated by many events such as post-translational modifications, degradation, and competitive binding of multiple TFs. In this review, with a particular emphasis on computational methods, we report the recent advances of the research topics related to transcriptional regulatory networks, including how to infer transcriptional interactions, reveal combinatorial regulation mechanisms, and reconstruct TF activity profiles. |
WOS研究方向 | Biochemistry & Molecular Biology ; Cell Biology |
语种 | 英语 |
出版者 | KOREAN SOC MOLECULAR & CELLULAR BIOLOGY |
WOS记录号 | WOS:000252248000001 |
内容类型 | 期刊论文 |
源URL | [http://ir.amss.ac.cn/handle/2S8OKBNM/4125] ![]() |
专题 | 中国科学院数学与系统科学研究院 |
通讯作者 | Chen, Luonan |
作者单位 | 1.Osaka Sangyo Univ, Dept Elect Informat & Commun Engn, Osaka 5748530, Japan 2.Renmin Univ China, Sch Informat, Beijing 100872, Peoples R China 3.CAS, Acad Math & Syst Sci, Beijing 100080, Peoples R China 4.Shanghai Univ, Inst Syst Biol, Shanghai 200444, Peoples R China 5.JST, ERATO Aihara Complex Modelling Project, Tokyo 1538530, Japan 6.Univ Tokyo, Inst Ind Sci, Tokyo 1538505, Japan |
推荐引用方式 GB/T 7714 | Wang, Rui-Sheng,Zhang, Xiang-Sun,Chen, Luonan. Inferring transcriptional interactions and regulator activities from experimental data[J]. MOLECULES AND CELLS,2007,24(3):307-315. |
APA | Wang, Rui-Sheng,Zhang, Xiang-Sun,&Chen, Luonan.(2007).Inferring transcriptional interactions and regulator activities from experimental data.MOLECULES AND CELLS,24(3),307-315. |
MLA | Wang, Rui-Sheng,et al."Inferring transcriptional interactions and regulator activities from experimental data".MOLECULES AND CELLS 24.3(2007):307-315. |
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