Gene's functional arrangement as a measure of the phylogenetic relationships of microorganisms

	Gene's functional arrangement as a measure of the phylogenetic relationships of microorganisms
	Wang, JH ; Fang, WW ; Ling, LJ ; Chen, RS
刊名	JOURNAL OF BIOLOGICAL PHYSICS
	2002
卷号	28 期号:1 页码:55-62
关键词	information theory phylogenetic trees sinteny whole genome analysis
ISSN号	0092-0606
英文摘要	With the development of genome sequencing more whole genomes of microorganisms were completed, many methods were introduced to reconstruct the phylogenetic tree of those microorganisms with the information extracted from the whole genomes through various ways of transforming or mapping the whole genome sequences into other forms which can describe the evolutionary distance in a new way. We think it might be possible that there exists information buried in the whole genome transferred along lineage, which remains stable and is more essential than sequence conservation of individual genes or the arrangement of some genes of a selected set. We need to find one measurement that can involve as many phylogenetic features as possible that are beyond the genome sequence itself. We converted each genome sequence of the microorganisms into another linear sequence to represent the functional structure of the sequence, and we used a new information function to calculate the discrepancy of sequences and to get one distance matrix of the genomes, and built one phylogenetic tree with a neighbor joining method. The resulting tree shows that the major lineages are consistent with the result based on their 16srRNA sequences. Our method discovered one phylogenetic feature derived from the genome sequences and the encoded genes that can rebuild the phylogenetic tree correctly. The mapping of one genome sequence to its new form representing the relative positions of the functional genes provides a new way to measure the phylogenetic relationships, and with the more specific classification of gene functions the result could be more sensitive.
WOS研究方向	Biophysics
语种	英语
出版者	KLUWER ACADEMIC PUBL
WOS记录号	WOS:000176805800005
内容类型	期刊论文
源URL	[http://ir.amss.ac.cn/handle/2S8OKBNM/17288]
专题	中国科学院数学与系统科学研究院
作者单位	1.Chinese Acad Sci, Inst Biophys, Lab Bioinformat, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Acad Math & Syst Sci, Beijing 100080, Peoples R China
推荐引用方式 GB/T 7714	Wang, JH,Fang, WW,Ling, LJ,et al. Gene's functional arrangement as a measure of the phylogenetic relationships of microorganisms[J]. JOURNAL OF BIOLOGICAL PHYSICS,2002,28(1):55-62.
APA	Wang, JH,Fang, WW,Ling, LJ,&Chen, RS.(2002).Gene's functional arrangement as a measure of the phylogenetic relationships of microorganisms.JOURNAL OF BIOLOGICAL PHYSICS,28(1),55-62.
MLA	Wang, JH,et al."Gene's functional arrangement as a measure of the phylogenetic relationships of microorganisms".JOURNAL OF BIOLOGICAL PHYSICS 28.1(2002):55-62.