On the sample size requirement in genetic association tests when the proportion of false positives is controlled | |
Zou, GH; Zuo, YJ | |
刊名 | GENETICS |
2006 | |
卷号 | 172期号:1页码:687-691 |
ISSN号 | 0016-6731 |
DOI | 10.1534/genetics.105.049536 |
英文摘要 | With respect to the multiple-tests problem, recently an increasing amount of attention has been paid to control the false discovery rate (FDR), the positive false discovery rate (pFDR), and the proportion of false positives (PFP). The new approaches are generally believed to be more powerful than the classical Bonferroni one. This article focuses on the PFP approach. It demonstrates via examples in genetic association studies that the Bonferroni procedure can be more powerful than the PFP-control one and also shows the intrinsic connection between controlling the PFP and controlling the overall type I error rate. Since controlling the PFP does not necessarily lead to a desired power level, this article addresses the design issue and recommends the sample sizes that can attain the desired power levels when the PFP is controlled. The results in this article also provide rough guidance for the sample sizes to achieve the desired power levels when the FDR and especially the pFDR are controlled. |
WOS研究方向 | Genetics & Heredity |
语种 | 英语 |
出版者 | GENETICS |
WOS记录号 | WOS:000235197700058 |
内容类型 | 期刊论文 |
源URL | [http://ir.amss.ac.cn/handle/2S8OKBNM/3377] |
专题 | 中国科学院数学与系统科学研究院 |
通讯作者 | Zou, GH |
作者单位 | 1.Michigan State Univ, Dept Stat & Probabil, E Lansing, MI 48824 USA 2.Chinese Acad Sci, Acad Math & Syst Sci, Beijing 100080, Peoples R China |
推荐引用方式 GB/T 7714 | Zou, GH,Zuo, YJ. On the sample size requirement in genetic association tests when the proportion of false positives is controlled[J]. GENETICS,2006,172(1):687-691. |
APA | Zou, GH,&Zuo, YJ.(2006).On the sample size requirement in genetic association tests when the proportion of false positives is controlled.GENETICS,172(1),687-691. |
MLA | Zou, GH,et al."On the sample size requirement in genetic association tests when the proportion of false positives is controlled".GENETICS 172.1(2006):687-691. |
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