The progressive supranuclear palsy patients exhibited lower levels of serum cholesterol and protein levels: a retrospective study

	The progressive supranuclear palsy patients exhibited lower levels of serum cholesterol and protein levels: a retrospective study
	Feng, T; Dan BC(单保慈); Nie BB(聂彬彬); Shan, BC; Nie, BB; Zhan, J; Huo, Q; Wang, GH
刊名	INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
	2016
卷号	9 期号:8 页码:16807
关键词	Serum cholesterol serum protein parkinson disease progressive supranuclear palsy
英文摘要	Many studies have showed that the serum cholesterol levels existed significant difference between Parkinson's disease (PD) patients and health controls. However, the serum cholesterol level in progressive supranuclear palsy (PSP) has not been studied. The object of this paper was to examine the levels of serum cholesterol and protein of PSP and their change in the disease progression. 57 possible PSP patients were collected in Beijing Tiantan Hospital from 2002 to 2014. The serum cholesterol and protein level of 57 patients were compared with 89 age-and sex-matched controls. In the 57 PSP patients, 12 patients have been in hospital two or more times. The data of these 12 patients were further analyzed to explore the changes of serum total cholesterol (TC) or total protein (TP) with the course of disease. Our findings showed that the serum TC and TP levels in patients were significantly lower than control. Multivariate logistics regression analysis showed that both TP and TC were independently associated with PSP. The serum protein and cholesterol levels further reduced from first hospitalization to the last time. The results implied that the serum protein and serum cholesterol might played a critical role in the development of PSP.
WOS记录号	WOS:000385837700225
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/260525]
专题	中国科学院高能物理研究所
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Feng, T,Dan BC,Nie BB,et al. The progressive supranuclear palsy patients exhibited lower levels of serum cholesterol and protein levels: a retrospective study[J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,2016,9(8):16807.
APA	Feng, T.,单保慈.,聂彬彬.,Shan, BC.,Nie, BB.,...&Wang, GH.(2016).The progressive supranuclear palsy patients exhibited lower levels of serum cholesterol and protein levels: a retrospective study.INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,9(8),16807.
MLA	Feng, T,et al."The progressive supranuclear palsy patients exhibited lower levels of serum cholesterol and protein levels: a retrospective study".INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE 9.8(2016):16807.