Investigating the stability of gold nanorods modified with thiol molecules for biosensing

doi:10.1039/c5ra22133a

	Investigating the stability of gold nanorods modified with thiol molecules for biosensing
	Gong YX(宫永翔); Liu J(刘建); Liu RC(刘润聪); Wang JJ(王娇娇); Zhu WF(朱文凤); Li M(李敏); Zhao YL(赵宇亮); Gong, YX; Liu, J; Liu, RC
刊名	RSC ADVANCES
	2016
卷号	6 期号:1 页码:174-178
DOI	10.1039/c5ra22133a
通讯作者	李敏 ; 赵宇亮
文献子类	期刊论文
英文摘要	Gold nanorods (GNRs) modified with functional molecules are useful in chemical and biological sensing. In this work, the extinction spectrum of purified GNRs prepared by seed-mediated growth is systematically characterized by UV-visible absorption spectroscopy to test its stability before and after alkane-thiol modification. The results show that purification of GNRs makes the GNRs less stable, while a GNRs colloid solution functionalized by 11-mercaptoundecanoic acid (MUA), 3,30-dithiobis[6-nitrobenzoic acid] bis(succinimide) ester (DSNB), or 16-mercaptohexadecanoic acid (MHA), respectively is stable over time. Bovine serum albumin (BSA) as a sample protein can be successfully attached to DSNB modified GNRs and form stable BSA-DSNB-GNRs probes. The red-shift observed in the extinction spectrum due to the BSA attachment is consistent over repeated experiments. Finally, anti-PSA (prostate-specific antigen) as a capture antibody is also attached to DSNB-modified GNRs. The attached anti-PSA is capable of interacting with prostate-specific antigens and induces a further red-shift, suggesting potential applications of thiol modified GNRs in bio-sensing.
WOS关键词	PLASMON RESONANCE SPECTROSCOPY ; ENHANCED RAMAN-SCATTERING ; NANOPARTICLES ; ABSORPTION ; THERAPY ; BIOCHIP
语种	英语
WOS记录号	WOS:000367250900022
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/260438]
专题	高能物理研究所_多学科研究中心
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Gong YX,Liu J,Liu RC,et al. Investigating the stability of gold nanorods modified with thiol molecules for biosensing[J]. RSC ADVANCES,2016,6(1):174-178.
APA	宫永翔.,刘建.,刘润聪.,王娇娇.,朱文凤.,...&Zhao, YL.(2016).Investigating the stability of gold nanorods modified with thiol molecules for biosensing.RSC ADVANCES,6(1),174-178.
MLA	宫永翔,et al."Investigating the stability of gold nanorods modified with thiol molecules for biosensing".RSC ADVANCES 6.1(2016):174-178.