Good Biocompatibility and Sintering Properties of Zirconia Nanoparticles Synthesized via Vapor-phase Hydrolysis

doi:10.1038/srep35020

	Good Biocompatibility and Sintering Properties of Zirconia Nanoparticles Synthesized via Vapor-phase Hydrolysis
	Wang, JG; Chen, SW; Guo, M; Wang, Q; He, X; Yin WY(尹文艳); He X(何潇); Yin, WY
刊名	SCIENTIFIC REPORTS
	2016
卷号	6
DOI	10.1038/srep35020
其他题名	放射性碘分子在Cu2O表面的吸附：第一性原理密度泛函研究
通讯作者	尹文艳
英文摘要	ZrO2 nanoparticles were synthesized by a vapor-phase hydrolysis process, and characterized in terms of crystalline structures, hardness and microstructures by X-ray diffraction, Vickers hardness test method, and atomic force microscopy (AFM) measurements. Moreover, in vitro cytotoxicity evaluation and hemolysis assay showed that the nanoparticles possessed good biocompatibility. Hardness investigations and AFM measurements indicated that both the sintering temperature and compression force played an important role in determining the physical behaviors (hardness, roughness and density) of flakes of the ZrO2 nanoparticles. When ZrO2 nanoparticles synthesized at 500 degrees C were pressed into flakes under 6 MPa and sintered at 1400 degrees C, the resulting flakes exhibited an optimal combination of hardness (534.58 gf.mm(-2)), roughness (0.07 mu m) and density (4.41 g.cm(-3)). As the Vickers hardness value of human bones is of 315 similar to 535 gf.mm(-2) and the density of adult femuris about 1.3 similar to 1.7 g.cm(-3), the experimental results showed that the ZrO2 flakes were comparable to human bones with a higher density. As a result, the synthesized ZrO2 NPs may be useful for biomedical applications, especially for bone repair and replacement in future.
语种	英语
WOS记录号	WOS:000385063800003
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/260400]
专题	高能物理研究所_多学科研究中心
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Wang, JG,Chen, SW,Guo, M,et al. Good Biocompatibility and Sintering Properties of Zirconia Nanoparticles Synthesized via Vapor-phase Hydrolysis[J]. SCIENTIFIC REPORTS,2016,6.
APA	Wang, JG.,Chen, SW.,Guo, M.,Wang, Q.,He, X.,...&Yin, WY.(2016).Good Biocompatibility and Sintering Properties of Zirconia Nanoparticles Synthesized via Vapor-phase Hydrolysis.SCIENTIFIC REPORTS,6.
MLA	Wang, JG,et al."Good Biocompatibility and Sintering Properties of Zirconia Nanoparticles Synthesized via Vapor-phase Hydrolysis".SCIENTIFIC REPORTS 6(2016).