Facet Energy versus Enzyme-like Activities: The Unexpected Protection of Palladium Nanocrystals against Oxidative Damage

doi:10.1021/acsnano.6b06297

	Facet Energy versus Enzyme-like Activities: The Unexpected Protection of Palladium Nanocrystals against Oxidative Damage
	Ge, CC; Fang, G; Shen, XM; Chong, Y; Wamer, WG; Gao, XF; Chai, ZF; Chen, CY; Yin, JJ; Chen CY(陈春英)
刊名	ACS NANO
	2016
卷号	10 期号:11 页码:10436-10445
关键词	palladium nanocrystals surface facet enzyme-like activity antioxidants computational chemistry oxidative stress
DOI	10.1021/acsnano.6b06297
通讯作者	陈春英
文献子类	期刊论文
英文摘要	To develop nanomaterials as artificial enzymes, it is necessary to better understand how their physicochemical properties affect their enzyme-like activities. Although prior research has demonstrated that nanomaterials exhibit tunable enzyme-like activities depending on their size, structure, and composition, few studies have examined the effect of surface facets, which determine surface energy or surface reactivity. Here, we use electron spin-resonance spectroscopy to report that lower surface energy {111}-faceted Pd octahedrons have greater intrinsic antioxidant enzyme like activity than higher surface energy {100}-faceted Pd nanocubes. Our in vitro experiments found that those same Pd octahedrons are more effective than Pd nanocubes at scavenging reactive oxygen species (ROS). Those reductions in ROS preserve the homogeneity of mitochondrial membrane potential and attenuate damage to important biomolecules, thereby allowing a substantially higher number of cells to survive oxidative challenges. Our computations of molecular mechanisms for the antioxidant activities of {111}- and {100}-faceted Pd nanocrystals, as well as their activity order, agree well with experimental observations. These findings can guide the design of antioxidant-mimicking nanomaterials, which could have therapeutic or preventative potential against oxidative stress related diseases.
WOS关键词	METAL-ORGANIC FRAMEWORKS ; PEROXIDASE-LIKE ACTIVITY ; AUGMENTED-WAVE METHOD ; REACTIVE OXYGEN ; CATALYTIC-ACTIVITY ; ARTIFICIAL ENZYMES ; DNA-DAMAGE ; GLUTATHIONE-PEROXIDASE ; OXIDE NANOPARTICLES ; MOLECULAR-OXYGEN
语种	英语
WOS记录号	WOS:000388913100075
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/260356]
专题	中国科学院高能物理研究所
通讯作者	Gao, Xingfa
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Ge, CC,Fang, G,Shen, XM,et al. Facet Energy versus Enzyme-like Activities: The Unexpected Protection of Palladium Nanocrystals against Oxidative Damage[J]. ACS NANO,2016,10(11):10436-10445.
APA	Ge, CC.,Fang, G.,Shen, XM.,Chong, Y.,Wamer, WG.,...&Chai, Zhifang.(2016).Facet Energy versus Enzyme-like Activities: The Unexpected Protection of Palladium Nanocrystals against Oxidative Damage.ACS NANO,10(11),10436-10445.
MLA	Ge, CC,et al."Facet Energy versus Enzyme-like Activities: The Unexpected Protection of Palladium Nanocrystals against Oxidative Damage".ACS NANO 10.11(2016):10436-10445.