Polyhydroxylated fullerenols regulate macrophage for cancer adoptive immunotherapy and greatly inhibit the tumor metastasis

doi:10.1016/j.nano.2015.11.021

	Polyhydroxylated fullerenols regulate macrophage for cancer adoptive immunotherapy and greatly inhibit the tumor metastasis
	Bai R(白茹); Zhou HG(周慧鸽); Liu J(刘晶); Dong JQ(董金泉); Sun BY(孙宝云); Chen ZY(陈志云); Tang JL(唐敬龙); Zhou, HG; Wang, LM; Bai, R
刊名	NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
	2016
卷号	12 期号:4 页码:945-954
关键词	Macrophage Adoptive immunotherapy Fullerenol Cancer
DOI	10.1016/j.nano.2015.11.021
通讯作者	刘颖
英文摘要	Adoptive immunotherapy is a highly effective approach for cancer treatment. Several potential adoptive immunotherapies have high (though reversible) toxicities with disappointing results. Polyhydroxylated fullerenols have been demonstrated as promising antitumor drugs with low toxicities. In this study, we investigate whether polyhydroxylated fullerenols (C-60(OH)(22) and Gd@C-82(OH)(22)) contribute to cancer immunotherapy by regulating macrophages. Our results show that fullerenols treatment enhances mitochondrial metabolism, phagocytosis and cytokine secretion. Moreover, activated macrophages inhibit the growth of several cancer cell types. It is likely that this inhibition is dependent on an NF-kappa B-mediated release of multiple cytokines. Using a lung metastasis model, we also show that autologous macrophages greatly suppress cancer cell metastasis to lung when they are activated by C-60(OH)(22) and Gd@C-82(OH)(22). More importantly, Gd@C-82(OH)(22) are shown to have stronger ability than C-60(OH)(22) to improve the macrophage function, which shed light on the rational design for nanomedicine and clinical application. From the Clinical Editor: The interest in the use of immunotherapy in cancer has rekindled recently. However, many approaches have shown disappointing results. In this study, the authors investigated the effects of polyhydroxylated fullerenol nanoparticles on regulating macrophages for immunotherapy. These positive findings may point a novel way to cancer treatment. (C) 2015 Elsevier Inc. All rights reserved.
语种	英语
WOS记录号	WOS:000375577300009
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/260301]
专题	高能物理研究所_多学科研究中心
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Bai R,Zhou HG,Liu J,et al. Polyhydroxylated fullerenols regulate macrophage for cancer adoptive immunotherapy and greatly inhibit the tumor metastasis[J]. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,2016,12(4):945-954.
APA	白茹.,周慧鸽.,刘晶.,董金泉.,孙宝云.,...&王黎明.(2016).Polyhydroxylated fullerenols regulate macrophage for cancer adoptive immunotherapy and greatly inhibit the tumor metastasis.NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,12(4),945-954.
MLA	白茹,et al."Polyhydroxylated fullerenols regulate macrophage for cancer adoptive immunotherapy and greatly inhibit the tumor metastasis".NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE 12.4(2016):945-954.