Initiation Mechanism of Kinesin's Neck Linker Docking Process

doi:http://dx.doi.org/10.1088/0256-307X/34/2/028701

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	Initiation Mechanism of Kinesin's Neck Linker Docking Process
	Geng, YZ; Zhang, H; Lyu, G; Ji, Q; Ji, Q (reprint author), Hebei Univ Technol, Inst Biophys, Tianjin 300401, Peoples R China.; Ji, Q (reprint author), Hebei Univ Technol, Sch Sci, Tianjin 300401, Peoples R China.; Ji, Q (reprint author), Chinese Acad Sci, Inst Theoret Phys, State Key Lab Theoret Phys, Beijing 100190, Peoples R China.
刊名	CHINESE PHYSICS LETTERS
	2017
卷号	34 期号:2 页码:28701
DOI	http://dx.doi.org/10.1088/0256-307X/34/2/028701
英文摘要	The neck linker (NL) docking to the motor domain is the key force generation process of a kinesin motor. In the initiation step of NL docking the first three residues (LYS325, THR326 and ILE327 in 2KIN) of the NL must form an 'extra turn', thus the other parts of the NL could dock to the motor domain. How the extra turn is formed remains elusive. We investigate the extra turn formation mechanism using structure-based mechanical analysis via molecular dynamics simulation. We find that the motor head rotation induced by ATP binding first drives ILE327 to move towards a hydrophobic pocket on the motor domain. The driving force, together with the hydrophobic interaction of ILE327 with the hydrophobic pocket, then causes a clockwise rotation of THR326, breaks the locking of LYS325, and finally drives the extra turn formation. This extra turn formation mechanism provides a clear pathway from ATP binding to NL docking of kinesin.
学科主题	Physics
语种	英语
内容类型	期刊论文
源URL	[http://ir.itp.ac.cn/handle/311006/22133]
专题	理论物理研究所_理论物理所1978-2010年知识产出
通讯作者	Ji, Q (reprint author), Hebei Univ Technol, Inst Biophys, Tianjin 300401, Peoples R China.; Ji, Q (reprint author), Hebei Univ Technol, Sch Sci, Tianjin 300401, Peoples R China.; Ji, Q (reprint author), Chinese Acad Sci, Inst Theoret Phys, State Key Lab Theoret Phys, Beijing 100190, Peoples R China.
推荐引用方式 GB/T 7714	Geng, YZ,Zhang, H,Lyu, G,et al. Initiation Mechanism of Kinesin's Neck Linker Docking Process[J]. CHINESE PHYSICS LETTERS,2017,34(2):28701.
APA	Geng, YZ.,Zhang, H.,Lyu, G.,Ji, Q.,Ji, Q .,...&Ji, Q .(2017).Initiation Mechanism of Kinesin's Neck Linker Docking Process.CHINESE PHYSICS LETTERS,34(2),28701.
MLA	Geng, YZ,et al."Initiation Mechanism of Kinesin's Neck Linker Docking Process".CHINESE PHYSICS LETTERS 34.2(2017):28701.