3D-printed peristaltic microfluidic systems fabricated from thermoplastic elastomer

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	3D-printed peristaltic microfluidic systems fabricated from thermoplastic elastomer
	Kim, Min ; Tung, Steve ; Liu LQ(刘连庆); Wang JY(王敬依); McMullen, Carlton ; Yao P(姚萍); Jiao ND(焦念东); Kim, Jin-Woo
刊名	Microfluidics and Nanofluidics
	2017
卷号	21 期号:6 页码:1-13
关键词	Microfluidic system 3D printing Insulin detection
ISSN号	1613-4982
通讯作者	Liu LQ(刘连庆) ; Tung, Steve
产权排序	1
中文摘要	Recent advancements in 3D printing technology have provided a potential low-cost and time-saving alternative to conventional PDMS (polydimethylsiloxane)-based microfabrication for microfluidic systems. In addition to reducing the complexity of the fabrication procedure by eliminating such intermediate steps as molding and bonding, 3D printing also offers more flexibility in terms of structural design than the PDMS micromolding process. At present, 3D-printed microfluidic systems typically utilize a relatively ‘stiff’ printing material such as ABS (acrylonitrile butadiene styrene copolymers), which limits the implementation of large mechanical actuation for active pumping and mixing as routinely carried out in a PDMS system. In this paper, we report the development of an active 3D-printed microfluidic system with moving parts fabricated from a flexible thermoplastic elastomer (TPE). The 3D-printed microfluidic system consists of two pneumatically actuated micropumps and one micromixer. The completed system was successfully applied to the detection of low-level insulin concentration using a chemiluminescence immunoassay, and the test result compares favorably with a similarly designed PDMS microfluidic system. Prior to system fabrication and testing, the material properties of TPE were extensively evaluated. The result indicated that TPE is compatible with biological materials and its 3D-printed surface is hydrophilic as opposed to hydrophobic for a molded PDMS surface. The Young’s modulus of TPE is measured to be 16 MPa, which is approximately eight times higher than that of PDMS, but over one hundred times lower than that of ABS.
WOS标题词	Science & Technology ; Technology ; Physical Sciences
类目[WOS]	Nanoscience & Nanotechnology ; Instruments & Instrumentation ; Physics, Fluids & Plasmas
研究领域[WOS]	Science & Technology - Other Topics ; Instruments & Instrumentation ; Physics
关键词[WOS]	DEVICES ; MICROPUMPS ; GLASS ; CHIP
收录类别	SCI ; EI
语种	英语
WOS记录号	WOS:000404213400005
内容类型	期刊论文
源URL	[http://ir.sia.cn/handle/173321/20758]
专题	沈阳自动化研究所_机器人学研究室
作者单位	1.Department of Mechanical Engineering, University of Arkansas, Fayetteville, AR, United States 2.State Key Lab of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang, China 3.Bio/Nano Technology Laboratory, Department of Biological and Agricultural Engineering, Institute for Nanoscience and Engineering, University of Arkansas, Fayetteville, AR, United States 4.Department of Physics, Williams College, Williamstown, MA, United States 5.University of Chinese Academy of Sciences, Beijing, China
推荐引用方式 GB/T 7714	Kim, Min,Tung, Steve,Liu LQ,et al. 3D-printed peristaltic microfluidic systems fabricated from thermoplastic elastomer[J]. Microfluidics and Nanofluidics,2017,21(6):1-13.
APA	Kim, Min.,Tung, Steve.,Liu LQ.,Wang JY.,McMullen, Carlton.,...&Kim, Jin-Woo.(2017).3D-printed peristaltic microfluidic systems fabricated from thermoplastic elastomer.Microfluidics and Nanofluidics,21(6),1-13.
MLA	Kim, Min,et al."3D-printed peristaltic microfluidic systems fabricated from thermoplastic elastomer".Microfluidics and Nanofluidics 21.6(2017):1-13.