APOE and KIBRA Interactions on Brain Functional Connectivity in Healthy Young Adults

doi:10.1093/cercor/bhw276

	APOE and KIBRA Interactions on Brain Functional Connectivity in Healthy Young Adults
	Zhang, Ningnannan 1,2; Liu, Huaigui 1,2; Qin, Wen 1,2; Liu, Bing3 ; Jiang, Tianzi3 ; Yu, Chunshui 1,2
刊名	CEREBRAL CORTEX
	2017-10-01
卷号	27 期号:10 页码:4797-4805
关键词	Apoe Functional Connectivity Density Functional Magnetic Resonance Imaging Genetic Interaction Kibra
DOI	10.1093/cercor/bhw276
文献子类	Article
英文摘要	Genetic variations of APOE and KIBRA have been associated with human memory and Alzheimer's disease. APOE and KIBRA can jointly modulate glutamate receptor to influence long-term potentiation; however, their interactions on brain functional connectivity remain unknown. Here, we investigated additive and epistatic interactions between APOE and KIBRA (rs17070145) on brain functional connectivity density (FCD) in 267 healthy young adults. A voxel-based FCD analysis was performed to identify brain regions with significant APOE-KIBRA interaction. Additive effects showed decreased FCD in the left parahippocampal gyrus and the right middle temporal gyrus and increased FCD in the bilateral middle occipital gyri, with the increase of the number of the risk-alleles of APOE and KIBRA. Epistatic effects showed APOE x KIBRA interaction in the FCD of the dorsolateral prefrontal cortex (DLPFC). The FCD of the DLPFC showed APOE risk-allele-dependent reduction (epsilon 2 > epsilon 3 > epsilon 4) in KIBRA TT homozygotes, but APOE risk-allele-dependent increase (epsilon 2 < epsilon 3 < epsilon 4) in KIBRA C-carriers. FCD differences were only significant between the 2 extreme subgroups in both additive and epistatic analyses. These findings suggest that APOE and KIBRA have region-dependent additive and epistatic interactions on brain connectivity in healthy young adults.
WOS关键词	DORSOLATERAL PREFRONTAL CORTEX ; AGE-DEPENDENT ASSOCIATION ; ALZHEIMERS-DISEASE RISK ; WORKING-MEMORY ; EPSILON-4 ALLELE ; SYNAPTIC PLASTICITY ; HIPPOCAMPAL VOLUME ; GENE POLYMORPHISM ; RECEPTOR FUNCTION ; INDIVIDUALS
WOS研究方向	Neurosciences & Neurology
语种	英语
WOS记录号	WOS:000410394400010
资助机构	National Natural Science Foundation of China(81301202 ; 81301217 ; 81425013 ; 91332113 ; 81271551)
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/20327]
专题	自动化研究所_脑网络组研究中心
作者单位	1.Tianjin Med Univ, Gen Hosp, Dept Radiol, 154 Anshan Rd, Tianjin 300052, Peoples R China 2.Tianjin Med Univ, Gen Hosp, Tianjin Key Lab Funct Imaging, Tianjin 300052, Peoples R China 3.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Ningnannan,Liu, Huaigui,Qin, Wen,et al. APOE and KIBRA Interactions on Brain Functional Connectivity in Healthy Young Adults[J]. CEREBRAL CORTEX,2017,27(10):4797-4805.
APA	Zhang, Ningnannan,Liu, Huaigui,Qin, Wen,Liu, Bing,Jiang, Tianzi,&Yu, Chunshui.(2017).APOE and KIBRA Interactions on Brain Functional Connectivity in Healthy Young Adults.CEREBRAL CORTEX,27(10),4797-4805.
MLA	Zhang, Ningnannan,et al."APOE and KIBRA Interactions on Brain Functional Connectivity in Healthy Young Adults".CEREBRAL CORTEX 27.10(2017):4797-4805.