Sex-specific neural circuits of emotion regulation in the centromedial amygdala

doi:10.1038/srep23112

	Sex-specific neural circuits of emotion regulation in the centromedial amygdala
	Wu, Yan 1; Li, Huandong2,3 ; Zhou, Yuan 4; Yu, Jian 1; Zhang, Yuanchao 1; Song, Ming2,3 ; Qin, Wen 5; Yu, Chunshui 5; Jiang, Tianzi1,2,3,6,7
刊名	SCIENTIFIC REPORTS
	2016-03-23
卷号	6
DOI	10.1038/srep23112
文献子类	Article
英文摘要	Sex-related differences in emotion regulation (ER) in the frequency power distribution within the human amygdala, a brain region involved in emotion processing, have been reported. However, how sex differences in ER are manifested in the brain networks which are seeded on the amygdala subregions is unclear. The goal of this study was to investigate this issue from a brain network perspective. Utilizing resting-state functional connectivity (RSFC) analysis, we found that the sex-specific functional connectivity patterns associated with ER trait level were only seeded in the centromedial amygdala (CM). Women with a higher trait-level ER had a stronger negative RSFC between the right CM and the medial superior frontal gyrus (mSFG), and stronger positive RSFC between the right CM and the anterior insula (AI) and the superior temporal gyrus (STG). But men with a higher trait-level ER was associated with weaker negative RSFC of the right CM-mSFG and positive RSFCs of the right CM-left AI, right CM-right AI/STG, and right CM-left STG. These results provide evidence for the sex-related effects in ER based on CM and indicate that men and women may differ in the neural circuits associated with emotion representation and integration.
WOS关键词	STATE FUNCTIONAL CONNECTIVITY ; INFERIOR FRONTAL GYRUS ; INDIVIDUAL-DIFFERENCES ; GENDER-DIFFERENCES ; COGNITIVE CONTROL ; EXTENDED AMYGDALA ; HUMAN BRAIN ; FMRI ; BEHAVIOR ; RESPONSES
WOS研究方向	Science & Technology - Other Topics
语种	英语
WOS记录号	WOS:000372608700001
资助机构	National Key Basic Research and Development Program (973)(2011CB707800) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDB02030300) ; Natural Science Foundation of China(91132301 ; Applied Basic Program of the Sichuan Province Department(2013JY0169) ; Sichuan Key Science & Technology Support Program of China(2014SZOO20) ; 91432302)
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/11381]
专题	自动化研究所_脑网络组研究中心
作者单位	1.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Key Lab NeuroInformat, Minist Educ, Chengdu 610054, Peoples R China 2.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China 3.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China 4.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing 100101, Peoples R China 5.Tianjin Med Univ, Dept Radiol, Gen Hosp, Tianjin 300052, Peoples R China 6.Chinese Acad Sci, Inst Automat, CAS Ctr Excellence Brain Sci, Beijing 100190, Peoples R China 7.Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia
推荐引用方式 GB/T 7714	Wu, Yan,Li, Huandong,Zhou, Yuan,et al. Sex-specific neural circuits of emotion regulation in the centromedial amygdala[J]. SCIENTIFIC REPORTS,2016,6.
APA	Wu, Yan.,Li, Huandong.,Zhou, Yuan.,Yu, Jian.,Zhang, Yuanchao.,...&Jiang, Tianzi.(2016).Sex-specific neural circuits of emotion regulation in the centromedial amygdala.SCIENTIFIC REPORTS,6.
MLA	Wu, Yan,et al."Sex-specific neural circuits of emotion regulation in the centromedial amygdala".SCIENTIFIC REPORTS 6(2016).