Progressive Thinning of Visual Motion area in lower limb amputees

doi:10.3389/fnhum.2016.00079

	Progressive Thinning of Visual Motion area in lower limb amputees
	Jiang, Guangyao 1; Li, Chuanming 1; Wu, Jixiang 2; Jiang, Tianzi3 ; Zhang, Yi 4; Zhao, Lu 5; Evans, Alan C.5; Li, Lei 2; Ran, Shuhua 1; Yin, Xuntao 1,5
刊名	FRONTIERS IN HUMAN NEUROSCIENCE
	2016-03-01
卷号	10
DOI	10.3389/fnhum.2016.00079
文献子类	Article
英文摘要	Accumulating evidence has indicated that amputation or deafferentation of a limb induces functional or structural reorganization in the visual areas. However, the extent of the visual areas involved after lower limb amputation remains uncertain. In this investigation, we studied 48 adult patients with unilateral lower limb amputation and 48 matched healthy controls using T1-weighted magnetic resonance imaging. Template-based regions of interest analysis was implemented to detect the changes of cortical thickness in the specific visual areas. Compared with normal controls, amputees exhibited significantly lower thickness in the V5/middle temporal (V5/MT+) visual area, as well as a trend of cortical thinning in the V3d. There was no significant difference in the other visual areas between the two groups. In addition, no significant difference of cortical thickness was found between patients with amputation at different levels. Across all amputees, correlation analyses revealed that the cortical thickness of the V5/MT+ was negatively correlated to the time since amputation. In conclusion, our findings indicate that the amputation of unilateral lower limb could induce changes in the motor-related visual cortex and provide an update on the plasticity of the human brain after limb injury.
WOS关键词	MAGNETIC-RESONANCE IMAGES ; COORDINATE SYSTEM ; MATTER CHANGES ; HUMAN HOMOLOG ; MOTOR CORTEX ; PAIN ; AMPUTATION ; BRAIN ; REORGANIZATION ; STIMULATION
WOS研究方向	Neurosciences & Neurology ; Psychology
语种	英语
WOS记录号	WOS:000371166100001
资助机构	National Natural Science Foundation of China for Young Scholars(81301205) ; Open Project Program of the National Laboratory of Pattern Recognition (NLPR) in China(201306283)
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/11359]
专题	自动化研究所_脑网络组研究中心
作者单位	1.Third Mil Med Univ, Southwest Hosp, Dept Radiol, Chongqing, Peoples R China 2.Third Mil Med Univ, Southwest Hosp, Dept Rehabil, Chongqing, Peoples R China 3.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China 4.Tradit Chinese Med Hosp Taiwan, Dept Osteol, Taipei, Taiwan 5.McGill Univ, Montreal Neurol Inst, McConnell Brain Imaging Ctr, Montreal, PQ, Canada
推荐引用方式 GB/T 7714	Jiang, Guangyao,Li, Chuanming,Wu, Jixiang,et al. Progressive Thinning of Visual Motion area in lower limb amputees[J]. FRONTIERS IN HUMAN NEUROSCIENCE,2016,10.
APA	Jiang, Guangyao.,Li, Chuanming.,Wu, Jixiang.,Jiang, Tianzi.,Zhang, Yi.,...&Wang, Jian.(2016).Progressive Thinning of Visual Motion area in lower limb amputees.FRONTIERS IN HUMAN NEUROSCIENCE,10.
MLA	Jiang, Guangyao,et al."Progressive Thinning of Visual Motion area in lower limb amputees".FRONTIERS IN HUMAN NEUROSCIENCE 10(2016).