Advanced nanomaterials targeting hypoxia to enhance radiotherapy | |
Jia Li; Wenting Shang![]() ![]() | |
刊名 | INTERNATIONAL JOURNAL OF NANOMEDICINE
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2018 | |
卷号 | 13页码:5925-5936 |
关键词 | radiotherapy hypoxia nanomaterials hypoxia inducible factor 1 |
ISSN号 | 1178-2013 |
DOI | 10.2147/IJN.S173914 |
通讯作者 | Tian, Jie(jie.tian@ia.ac.cn) ; Lu, Ligong(luligong1969@126.com) |
英文摘要 | Hypoxia within solid tumors is often responsible for the failure of radiotherapy. The development of hypoxia-targeting nanomaterials - aimed at enhancing the effect of radiotherapy by electrical or heat effects and at modulating hypoxia in the tumor microenvironment - is a promising strategy to address this issue. We provide an overview of recently developed advanced materials that potentiate radiotherapy. First, we summarize novel materials for oxygen delivery or production to modify the tumor microenvironment, thus improving the effects of ionizing radiation. Second, we present new approaches for the design of high-Z element-based multifunctional nanoplatforms to enhance radiotherapy. Third, novel drug delivery systems for hypoxic regions and hypoxia-inducible factor-1-targeted therapies are discussed. Fourth, we establish the effectiveness of X-ray-or near-infrared-responsive nanoparticles for selectively triggering therapeutic effects under hypoxic conditions. Finally, this review emphasizes the importance of research in the field of nanomedicine focused on tumor hypoxia to improve clinical outcomes. |
资助项目 | National Key Research and Development Program of China[2017YFA0205 200] ; National Natural Science Foundation of China[81571785] ; National Natural Science Foundation of China[81771957] ; National Natural Science Foundation of China[81502642] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[81527805] ; National Natural Science Foundation of China[61671449] ; National Natural Science Foundation of China[81501540] ; Natural Science Foundation of Guangdong Province, China[2016A030311055] ; Natural Science Foundation of Guangdong Province, China[2016A030313770] ; Natural Science Foundation of Guangdong Province, China[2015A030310108] ; Chinese Academy of Sciences[GJJSTD20170004] ; State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, Chinese Academy of Sciences[20180111] |
WOS关键词 | OVERCOME TUMOR HYPOXIA ; DRUG-DELIVERY SYSTEMS ; BREAST-CANCER CELLS ; GOLD NANOPARTICLES ; OXYGEN DELIVERY ; CLINICAL-APPLICATIONS ; RECTAL-CANCER ; IN-VIVO ; MULTIFUNCTIONAL NANOTHERANOSTICS ; POSTOPERATIVE CHEMORADIOTHERAPY |
WOS研究方向 | Science & Technology - Other Topics ; Pharmacology & Pharmacy |
语种 | 英语 |
出版者 | DOVE MEDICAL PRESS LTD |
WOS记录号 | WOS:000446664200001 |
资助机构 | National Key Research and Development Program of China ; National Natural Science Foundation of China ; Natural Science Foundation of Guangdong Province, China ; Chinese Academy of Sciences ; State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, Chinese Academy of Sciences |
内容类型 | 期刊论文 |
源URL | [http://ir.ia.ac.cn/handle/173211/22028] ![]() |
专题 | 自动化研究所_中国科学院分子影像重点实验室 |
作者单位 | 1.Zhuhai Precision Medical Center, Zhuhai People’s Hospital, Jinan University, Zhuhai, China 2.CAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing, China 3.Beijing Key Laboratory of Molecular Imaging, Beijing, China |
推荐引用方式 GB/T 7714 | Jia Li,Wenting Shang,Yong Li,et al. Advanced nanomaterials targeting hypoxia to enhance radiotherapy[J]. INTERNATIONAL JOURNAL OF NANOMEDICINE,2018,13:5925-5936. |
APA | Jia Li,Wenting Shang,Yong Li,Sirui Fu,Jie Tian,&Ligong Lu.(2018).Advanced nanomaterials targeting hypoxia to enhance radiotherapy.INTERNATIONAL JOURNAL OF NANOMEDICINE,13,5925-5936. |
MLA | Jia Li,et al."Advanced nanomaterials targeting hypoxia to enhance radiotherapy".INTERNATIONAL JOURNAL OF NANOMEDICINE 13(2018):5925-5936. |
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