Targeted polypyrrole nanoparticles for the identification and treatment of hepatocellular carcinoma

doi:10.1039/c8nr02036a

CORC > 自动化研究所 > 中国科学院自动化研究所 > 中国科学院分子影像重点实验室

	Targeted polypyrrole nanoparticles for the identification and treatment of hepatocellular carcinoma
	Jin, Yushen1,2 ; Yang, Xin1,2 ; Tian, Jie1,2,3,4
刊名	NANOSCALE
	2018-05-28
卷号	10 期号:20 页码:9594-9601
关键词	Polypyrrole Nanoparticles Photoacoustic And Near Infrared (Nir) Fluorescence Imaging Sp94 Peptide Hepatocellular Carcinoma Image-guided Photothermal Therapy
DOI	10.1039/c8nr02036a
文献子类	Article
英文摘要	Early identification and treatment of hepatocellular carcinoma is very important for improving the prognosis and survival rate of the patient. To enhance the visualization and treatment efficiency of HCC, a theranostic agent has been developed that combines photoacoustic/fluorescence imaging with photothermal therapy for cancer. We report the synthesis of multifunctional theranostic SP94-modified polypyrrole (PPy)-BSA-ICG nanoparticles by a simple method. The multifunctional theranostic agent helped to combine two modes of imaging modalities, i.e. photoacoustic and near infrared (NIR) fluorescence imaging, together with photothermal therapy. These nanoparticles exhibited an excellent stability in physiological solutions (PBS, pH 7.4 at 37 degrees C), a higher tumor accumulation as compared to the unmodified nanoparticles, and minimal nonspecific uptake by other normal organs such as liver and spleen. Most importantly, the nanoparticles could effectively kill the tumor through photothermal therapy with no tumor recurrence upon a single laser irradiation event. These results indicate that SP94-modified PPy-BSA-ICG is potentially a promising theranostic agent for image-guided cancer therapy as it overcomes the limitations of each of the imaging modalities and thus improves the therapeutic efficiency and reduces the side effects.
WOS关键词	GUIDED-PHOTOTHERMAL THERAPY ; THERANOSTIC AGENT ; INDOCYANINE GREEN ; GOLD NANOCAGES ; PRUSSIAN BLUE ; CUS NANOPARTICLES ; TANTALUM OXIDE ; DUAL-MODALITY ; CANCER ; FLUORESCENCE
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
WOS记录号	WOS:000433260300019
资助机构	National Key Research and Development Program of China(2017YFA0205200 ; National Natural Science Foundation of China(81227901 ; International Innovation Team of CAS(20140491524) ; Beijing Municipal Science & Technology Commission(Z161100002616022) ; 2015CB755500 ; 81527805 ; 2016YFA0201401) ; 81701771 ; 61231004)
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/21693]
专题	自动化研究所_中国科学院分子影像重点实验室
作者单位	1.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China 2.Beijing Key Lab Mol Imaging, Beijing 100190, Peoples R China 3.Chinese Acad Sci, Inst Automat, State Key Lab Management & Control Complex Syst, Beijing 100190, Peoples R China 4.Univ Chinese Acad Sci, Sch Artificial Intelligence, Beijing 100080, Peoples R China
推荐引用方式 GB/T 7714	Jin, Yushen,Yang, Xin,Tian, Jie. Targeted polypyrrole nanoparticles for the identification and treatment of hepatocellular carcinoma[J]. NANOSCALE,2018,10(20):9594-9601.
APA	Jin, Yushen,Yang, Xin,&Tian, Jie.(2018).Targeted polypyrrole nanoparticles for the identification and treatment of hepatocellular carcinoma.NANOSCALE,10(20),9594-9601.
MLA	Jin, Yushen,et al."Targeted polypyrrole nanoparticles for the identification and treatment of hepatocellular carcinoma".NANOSCALE 10.20(2018):9594-9601.