Dye-conjugated single-walled carbon nanotubes induce photothermal therapy under the guidance of near-infrared imaging | |
Liang, Xiaoyuan1,2,3; Shang, Wenting2,3; Chi, Chongwei2,3; Zeng, Chaoting1; Wang, Kun2,3; Fang, Chihua1; Chen, Qingshan1; Liu, Huiyu4; Fan, Yingfang1; Tian, Jie2,3 | |
刊名 | CANCER LETTERS |
2016-12-28 | |
卷号 | 383期号:2页码:243-249 |
关键词 | Photothermal Therapy (Ptt) Near-infrared Imaging (Nir) Single-walled Carbon Nanotubes Cy5.5 |
DOI | 10.1016/j.canlet.2016.09.006 |
文献子类 | Article |
英文摘要 | Recently, photothermal therapy (PTT) has become viewed as an ideal auxiliary therapeutic treatment for cancers. However, the development of safe, convenient, and highly effective photothermal agents remains a great challenge. In this study, we prepared single-walled carbon nanotubes (SWNTs) for PIT against breast tumors under the guidance of infrared fluorescent cyanines. Tumors were accurately located using near-infrared imaging (NIR) and then exposed to laser irradiation. Both the in vivo and in vitro results showed that the SWNTs have high stability and low cytotoxicity. Introducing polyethylene glycol into our nanoparticles increased the blood-circulation time. Our in vivo results further showed that Cy5.5-conjugated SWNTs mediated PTT, resulting in efficient tumor suppression in mice under the guidance of near-infrared imaging. Due to the small amount of absorption at 808-nm, Cy5.5 increased the efficiency of PTE Breast tumors significantly shrunk after irradiation under the 808-nm near-infrared laser. The treated mice developed scabs, but otherwise recovered after 15 days, and their physical conditions restored gradually. These data indicate that our unique photothermal-responsive SWNT-Cy5.5-based theranostic agent can serve as a promising candidate for PTT. (C) 2016 Elsevier Ireland Ltd. All rights reserved. |
WOS关键词 | CANCER-THERAPY ; FUNCTIONAL NANOMATERIALS ; GOLD NANOPARTICLES ; INDOCYANINE GREEN ; DRUG-DELIVERY ; CELLS ; NANOSTRUCTURES ; NANOMEDICINE ; THERANOSTICS ; HYPERTHERMIA |
WOS研究方向 | Oncology |
语种 | 英语 |
WOS记录号 | WOS:000388052900011 |
资助机构 | National High Technology Research and Development Program of China (863 Program)(2012AA021105) ; National Natural Science Foundation of China(81501540 ; Natural Science Foundation of China-Guangdong United Funds(U1401254) ; Science and Technology Planning Project of Guangdong Province, China(2015B031800091) ; Guangdong Province Science and Technology Plan Project(2016A020220013) ; Strategic Priority Research Program from Chinese Academy of Sciences(XDB02060010) ; 61501462) |
内容类型 | 期刊论文 |
源URL | [http://ir.ia.ac.cn/handle/173211/13343] |
专题 | 自动化研究所_中国科学院分子影像重点实验室 |
作者单位 | 1.Southern Med Univ, Zhujiang Hosp, Dept Heparobiliary Surg, Guangzhou 510280, Guangdong, Peoples R China 2.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China 3.Beijing Key Lab Mol Imaging, Beijing 100190, Peoples R China 4.Beijing Univ Chem Technol, Coll Life Sci & Technol, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Liang, Xiaoyuan,Shang, Wenting,Chi, Chongwei,et al. Dye-conjugated single-walled carbon nanotubes induce photothermal therapy under the guidance of near-infrared imaging[J]. CANCER LETTERS,2016,383(2):243-249. |
APA | Liang, Xiaoyuan.,Shang, Wenting.,Chi, Chongwei.,Zeng, Chaoting.,Wang, Kun.,...&Tian, Jie.(2016).Dye-conjugated single-walled carbon nanotubes induce photothermal therapy under the guidance of near-infrared imaging.CANCER LETTERS,383(2),243-249. |
MLA | Liang, Xiaoyuan,et al."Dye-conjugated single-walled carbon nanotubes induce photothermal therapy under the guidance of near-infrared imaging".CANCER LETTERS 383.2(2016):243-249. |
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