Striatum morphometry is associated with cognitive control deficits and symptom severity in internet gaming disorder

doi:10.1007/s11682-015-9358-8

CORC > 自动化研究所 > 中国科学院自动化研究所 > 中国科学院分子影像重点实验室

	Striatum morphometry is associated with cognitive control deficits and symptom severity in internet gaming disorder
	Cai, Chenxi 1,2; Yuan, Kai 1,2; Yin, Junsen 1,2; Feng, Dan 1,2; Bi, Yanzhi 1,2; Li, Yangding 1,2; Yu, Dahua 3; Jin, Chenwang 4; Qin, Wei 1,2; Tian, Jie1,2,5
刊名	BRAIN IMAGING AND BEHAVIOR
	2016-03-01
卷号	10 期号:1 页码:12-20
关键词	Cognitive Control Internet Gaming Disorder (Igd) Striatum Color-word Stroop Task Structural Magnetic Resonance Imaging
DOI	10.1007/s11682-015-9358-8
文献子类	Article
英文摘要	Internet gaming disorder (IGD), identified in the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-V) Section III as a condition warranting more clinical research, may be associated with impaired cognitive control. Previous IGD-related studies had revealed structural abnormalities in the prefrontal cortex, an important part of prefrontal-striatal circuits, which play critical roles in cognitive control. However, little is known about the relationship between the striatal nuclei (caudate, putamen, and nucleus accumbens) volumes and cognitive control deficit in individuals with IGD. Twenty-seven adolescents with IGD and 30 age-,gender-and education-matched healthy controls participated in this study. The volume differences of the striatum were assessed by measuring subcortical volume in FreeSurfer. Meanwhile, the Stroop task was used to detect cognitive control deficits. Correlation analysis was used to investigate the relationship between striatal volumes and performance in the Stroop task as well as severity in IGD. Relative to controls, the IGD committed more incongruent condition response errors during the Stroop task and showed increased volumes of dorsal striatum (caudate) and ventral striatum (nucleus accumbens). In addition, caudate volume was correlated with Stroop task performance and nucleus accumbens (NAc) volume was associated with the internet addiction test (IAT) score in the IGD group. The increased volumes of the right caudate and NAc and their association with behavioral characteristics (i.e., cognitive control and severity) in IGD were detected in the present study. Our findings suggest that the striatum may be implicated in the underlying pathophysiology of IGD.
WOS关键词	SUBSTANCE USE DISORDERS ; STROOP TASK ; ADDICTION ; BRAIN ; REWARD ; GAME ; ABNORMALITIES ; RESPONSES ; SMOKING ; RELEASE
WOS研究方向	Neurosciences & Neurology
语种	英语
WOS记录号	WOS:000377829500002
资助机构	Project for the National Key Basic Research and Development Program(2014CB543203 ; National Natural Science Foundation of China(81401478 ; Natural Science Basic Research Plan in Shaanxi Province of China(2014JQ4118) ; Fundamental Research Funds for the Central Universities(8002-72125760 ; Natural Science Foundation of Inner Mongolia(2012MS0908) ; China Post- doctoral Science Foundation(2014 M552416) ; 2011CB707700 ; 81401488 ; 8002-72135767 ; 2012CB518501) ; 81227901 ; 8002-72145760) ; 81271644 ; 81271546 ; 81101036 ; 81101108 ; 31200837 ; 81301281)
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/12045]
专题	自动化研究所_中国科学院分子影像重点实验室
通讯作者	Tian, Jie
作者单位	1.Xidian Univ, Sch Life Sci & Technol, Xian 710071, Shaanxi, Peoples R China 2.Minist Educ, Engn Res Ctr Mol & Neuro Imaging, Xian, Peoples R China 3.Inner Mongolia Univ Sci & Technol, Sch Informat Engn, Inner Mongolia Key Lab Pattern Recognit & Intelli, Baotou 014010, Inner Mongolia, Peoples R China 4.Xi An Jiao Tong Univ, Dept Med Imaging, Affiliated Hosp 1, Coll Med, Xian 710061, Shaanxi, Peoples R China 5.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Cai, Chenxi,Yuan, Kai,Yin, Junsen,et al. Striatum morphometry is associated with cognitive control deficits and symptom severity in internet gaming disorder[J]. BRAIN IMAGING AND BEHAVIOR,2016,10(1):12-20.
APA	Cai, Chenxi.,Yuan, Kai.,Yin, Junsen.,Feng, Dan.,Bi, Yanzhi.,...&Tian, Jie.(2016).Striatum morphometry is associated with cognitive control deficits and symptom severity in internet gaming disorder.BRAIN IMAGING AND BEHAVIOR,10(1),12-20.
MLA	Cai, Chenxi,et al."Striatum morphometry is associated with cognitive control deficits and symptom severity in internet gaming disorder".BRAIN IMAGING AND BEHAVIOR 10.1(2016):12-20.