Altered functional connectivity within and between the default model network and the visual network in primary open-angle glaucoma: a resting-state fMRI study

doi:10.1007/s11682-016-9597-3

CORC > 自动化研究所 > 中国科学院自动化研究所 > 复杂系统管理与控制国家重点实验室 > 影像分析与机器视觉团队

	Altered functional connectivity within and between the default model network and the visual network in primary open-angle glaucoma: a resting-state fMRI study
	Wang, Jieqiong1,2 ; Li, Ting 3; Zhou, Peng 1,2; Wang, Ningli 4; Xian, Junfang 3; He, Huiguang1,2,5
刊名	BRAIN IMAGING AND BEHAVIOR
	2017-08-01
卷号	11 期号:4 页码:1154-1163
关键词	Subnetwork Independent Component Analysis Glaucoma Functional Connectivity Functional Network Connectivity
DOI	10.1007/s11682-016-9597-3
文献子类	Article
英文摘要	To explore the alterations of functional connectivity (FC) and connections within and between the subnetworks of the visual network and the default mode network in glaucoma. We applied the independent component analysis to obtain two resting-state networks (RSNs), which were the visual network and the default mode network (DMN), from the resting-state fMRI data of 25 primary open-angle glaucoma (POAG) patients and 25 well-matched normal controls. Then FC analysis was performed to obtain the altered FC within the RSNs, whereas the functional network connectivity (FNC) analysis was performed within and between these two RSNs. The abnormalities were correlated with clinical measures in glaucoma to investigate the abnormality-clinical relationship. FC analysis showed that the FC in the occipital pole of the visual network was decreased in POAG patients while no alterations were found in the FC of the DMN in patients. FNC analysis of connections within the RSNs found that two of the three connections within the visual network were decreased while no connection alterations were found within the DMN. FNC analysis of connections between these two RSNs found two increased connections and one decreased connection. The decreased connection between these two RSNs was positively correlated with the visual field mean deviation. These findings shed light on the importance of the reorganization of resting state networks in glaucoma mechanism, which may facilitate the understanding of glaucoma.
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WOS关键词	LATERAL GENICULATE-NUCLEUS ; AGE-RELATED-CHANGES ; BLIND SEPARATION ; OPTIC-NERVE ; BRAIN ; STIMULATION ; COMPONENTS ; SCHIZOPHRENIA ; ABNORMALITIES ; RESPONSES
WOS研究方向	Neurosciences & Neurology
语种	英语
WOS记录号	WOS:000407840500022
资助机构	National Natural Science Foundation of China(61271151 ; Youth Innovation Promotion Association CAS ; 91520202 ; 81571649)
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/20596]
专题	自动化研究所_复杂系统管理与控制国家重点实验室_影像分析与机器视觉团队
作者单位	1.Chinese Acad Sci, Inst Automat, State Key Lab Management & Control Complex Syst, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Capital Med Univ, Beijing Tongren Hosp, Dept Radiol, Beijing, Peoples R China 4.Capital Med Univ, Beijing Tongren Hosp, Dept Ophthalmol, Beijing, Peoples R China 5.Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Wang, Jieqiong,Li, Ting,Zhou, Peng,et al. Altered functional connectivity within and between the default model network and the visual network in primary open-angle glaucoma: a resting-state fMRI study[J]. BRAIN IMAGING AND BEHAVIOR,2017,11(4):1154-1163.
APA	Wang, Jieqiong,Li, Ting,Zhou, Peng,Wang, Ningli,Xian, Junfang,&He, Huiguang.(2017).Altered functional connectivity within and between the default model network and the visual network in primary open-angle glaucoma: a resting-state fMRI study.BRAIN IMAGING AND BEHAVIOR,11(4),1154-1163.
MLA	Wang, Jieqiong,et al."Altered functional connectivity within and between the default model network and the visual network in primary open-angle glaucoma: a resting-state fMRI study".BRAIN IMAGING AND BEHAVIOR 11.4(2017):1154-1163.