Prolonged high-altitude residence impacts verbal working memory: an fMRI study

	Prolonged high-altitude residence impacts verbal working memory: an fMRI study
	Yan, Xiaodan 2,3,4; Zhang, Jiaxing 1,2; Gong, Qiyong 5; Weng, Xuchu 2; Zhang, JX (reprint author), Xiamen Univ, Dept Physiol, Coll Med, Xiamen, Peoples R China.
刊名	EXPERIMENTAL BRAIN RESEARCH
	2011-02-01
卷号	208 期号:3 页码:437-445
关键词	Working memory N-back Verbal Granger causality Effective connectivity fMRI
ISSN号	0014-4819
产权排序	1
文献子类	Article
英文摘要	Oxygen is critical to normal brain functioning and development. In high altitude where the oxygen concentration and pressure are very low, human cognitive capability such as working memory has been found to be jeopardized. Such effect might persist with long-term high-altitude residence. The current study investigated the verbal working memory of 28 high-altitude residents with blood level oxygen dependent (BOLD) functional magnetic resonance imaging (fMRI), in contrast with that of the 30 sea level residents. All of the subjects were healthy college students, matched on their age, gender ratio and social-economic status; they also did not show any difference on their hemoglobin level. The high-altitude subjects showed longer reaction time and decreased response accuracy in behavioral performance. Both groups showed activation in the typical regions associated with the 2-back verbal working memory task, and the behavioral performance of both groups showed significant correlations with the BOLD signal change amplitude and Granger causality values (as a measure of the interregional effective connectivity) between these regions. With group comparison statistics, the high-altitude subjects showed decreased activation at the inferior and middle frontal gyrus, the middle occipital and the lingual gyrus, the pyramis of vermis, as well as the thalamus. In conclusion, the current study revealed impairment in verbal working memory among high-altitude residents, which might be associated with the impact of prolonged chronic hypoxia exposure on the brain functionality.
学科主题	Cognitive Psychology,Environmental Psychology
URL标识	查看原文
资助项目	二室翁旭初课题组
语种	英语
WOS记录号	WOS:000286117700011
公开日期	2011-11-11
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/6934]
专题	心理研究所_认知与发展心理学研究室
通讯作者	Zhang, JX (reprint author), Xiamen Univ, Dept Physiol, Coll Med, Xiamen, Peoples R China.
作者单位	1.Xiamen Univ, Dept Physiol, Coll Med, Xiamen, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Lab Higher Brain Funct, Beijing 100101, Peoples R China 3.Rensselaer Polytech Inst, Dept Cognit Sci, Troy, NY USA 4.NYU, Langone Med Ctr, New York, NY USA 5.Sichuan Univ, Huaxi Magnet Resonance Res Ctr, W China Hosp, Chengdu 610064, Peoples R China
推荐引用方式 GB/T 7714	Yan, Xiaodan,Zhang, Jiaxing,Gong, Qiyong,et al. Prolonged high-altitude residence impacts verbal working memory: an fMRI study[J]. EXPERIMENTAL BRAIN RESEARCH,2011,208(3):437-445.
APA	Yan, Xiaodan,Zhang, Jiaxing,Gong, Qiyong,Weng, Xuchu,&Zhang, JX .(2011).Prolonged high-altitude residence impacts verbal working memory: an fMRI study.EXPERIMENTAL BRAIN RESEARCH,208(3),437-445.
MLA	Yan, Xiaodan,et al."Prolonged high-altitude residence impacts verbal working memory: an fMRI study".EXPERIMENTAL BRAIN RESEARCH 208.3(2011):437-445.