Effects of adolescent social isolation on the expression of brain-derived neurotrophic factors in the forebrain

	Effects of adolescent social isolation on the expression of brain-derived neurotrophic factors in the forebrain
	Meng, Qingxuan 1; Li, Nanxin 1,2; Han, Xiao 1; Shao, Feng 1; Wang, Weiwen3 ; Shao, F (reprint author), Peking Univ, Dept Psychol, 5 Yiheyuan Rd, Beijing 100871, Peoples R China.
刊名	EUROPEAN JOURNAL OF PHARMACOLOGY
	2011-01-10
卷号	650 期号:1 页码:229-232
关键词	Adolescent BDNF Frontal cortex Hippocampus Social isolation
ISSN号	0014-2999
产权排序	3
文献子类	Article
英文摘要	Adolescence is a critical period for the development of neural plasticity Social isolation is an important animal model for various neurodevelopmental disorders Brain derived neurotrophic factor (BDNF) mediates many important brain functions such as neural plasticity and aberrations in its expression have been implicated in many brain disorders However to date there have been few reports of effects of adolescent social isolation on BDNF expression in adult animals In the present study we subjected weaning Sprague Dawley rats to a four-week early adolescence social isolation procedure followed by lour-week standarad housing until adulthood for molecular assays BDNF protein levels in several key forebrain regions relevant to brain development were investigated using immunohistochemistry including frontal and cingulate cortex as well as hippocampus Our results show that adolescent social isolation significantly increased BDNF protein expression in the medial prefrontal cortex and all three sub fields of the hippocampus including CA I CA2/3 and dentate gyms This study advances the use of adolescent social isolation as an animal model for studying neurobiological underpinnings of various neurodevelopmental disorders (C) 2010 Elsevier B V All rights reserved
学科主题	Physiological Psychology/biological Psychology
URL标识	查看原文
资助项目	一室林文娟课题组
语种	英语
WOS记录号	WOS:000285893800031
公开日期	2011-11-11
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/6910]
专题	心理研究所_健康与遗传心理学研究室
通讯作者	Shao, F (reprint author), Peking Univ, Dept Psychol, 5 Yiheyuan Rd, Beijing 100871, Peoples R China.
作者单位	1.Peking Univ, Dept Psychol, Beijing 100871, Peoples R China 2.Yale Univ, Dept Psychol, Div Mol Psychiat, New Haven, CT 06508 USA 3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
推荐引用方式 GB/T 7714	Meng, Qingxuan,Li, Nanxin,Han, Xiao,et al. Effects of adolescent social isolation on the expression of brain-derived neurotrophic factors in the forebrain[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2011,650(1):229-232.
APA	Meng, Qingxuan,Li, Nanxin,Han, Xiao,Shao, Feng,Wang, Weiwen,&Shao, F .(2011).Effects of adolescent social isolation on the expression of brain-derived neurotrophic factors in the forebrain.EUROPEAN JOURNAL OF PHARMACOLOGY,650(1),229-232.
MLA	Meng, Qingxuan,et al."Effects of adolescent social isolation on the expression of brain-derived neurotrophic factors in the forebrain".EUROPEAN JOURNAL OF PHARMACOLOGY 650.1(2011):229-232.