Spared behavioral repetition effects in Alzheimer's disease linked to an altered neural mechanism at posterior cortex | |
Broster, Lucas S.1,2; Li, Juan1,3; Wagner, Benjamin1; Smith, Charles D.4,5,6; Jicha, Gregory A.4,5; Schmitt, Frederick A.2,4,5; Munro, Nancy7; Haney, Ryan H.1; Jiang, Yang1,5,6 | |
刊名 | JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY |
2018 | |
卷号 | 40期号:8页码:761-776 |
关键词 | Alzheimer's Disease Event-related Potentials Mild Cognitive Impairment Repetition Effects Working Memory |
ISSN号 | 1380-3395 |
DOI | 10.1080/13803395.2018.1430230 |
产权排序 | 3 |
文献子类 | Article |
英文摘要 | Objective: Individuals with dementia of the Alzheimer type (AD) classically show disproportionate impairment in measures of working memory, but repetition learning effects are relatively preserved. As AD affects brain regions implicated in both working memory and repetition effects, the neural basis of this discrepancy is poorly understood. We hypothesized that the posterior repetition effect could account for this discrepancy due to the milder effects of AD at visual cortex. Method: Participants with early AD, amnestic mild cognitive impairment (MCI), and healthy controls performed a working memory task with superimposed repetition effects while electroencephalography was collected to identify possible neural mechanisms of preserved repetition effects. Results: Participants with AD showed preserved behavioral repetition effects and a change in the posterior repetition effect. Conclusion: Visual cortex may play a role in maintained repetition effects in persons with early AD. |
资助项目 | University of Kentucky Department of Behavioral Science ; U.S. Department of Energy[DE-AC03-OR22725] ; National Institute of Health: National Institute on Aging[P50 AG05144-21] ; National Institute of Health: National Institute on Aging[AG000986] ; National Institute of Health: National Institute on Aging[5P30AG028383] ; National Institute of Health: National Institute on Aging[810 5 T32 AG 242-18] ; National Institute of Mental Health[R25 MH060482] ; National Center for Advancing Translational Sciences[UL1RR033173] ; National Center for Advancing Translational Sciences[UL1TR000117] |
WOS关键词 | Mild Cognitive Impairment ; Event-related Potentials ; Default-mode Network ; Working-memory ; Brain Activity ; Association Workgroups ; Diagnostic Guidelines ; National Institute ; Older Controls ; Dementia |
WOS研究方向 | Psychology ; Neurosciences & Neurology |
语种 | 英语 |
出版者 | TAYLOR & FRANCIS INC |
WOS记录号 | WOS:000445103200002 |
资助机构 | University of Kentucky Department of Behavioral Science ; U.S. Department of Energy ; National Institute of Health: National Institute on Aging ; National Institute of Mental Health ; National Center for Advancing Translational Sciences |
内容类型 | 期刊论文 |
源URL | [http://ir.psych.ac.cn/handle/311026/27008] |
专题 | 心理研究所_中国科学院心理健康重点实验室 |
通讯作者 | Broster, Lucas S. |
作者单位 | 1.Univ Kentucky, Coll Med, Dept Behav Sci, 113 Med Behav Sci Bldg, Lexington, KY 40536 USA 2.Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA 3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing, Peoples R China 4.Univ Kentucky, Dept Neurol, Coll Med, Lexington, KY 40536 USA 5.Univ Kentucky, Sanders Brown Ctr Aging, Coll Med, Lexington, KY 40536 USA 6.Univ Kentucky, Magnet Resonance Imaging & Spect Ctr, Coll Med, Lexington, KY 40536 USA 7.Oak Ridge Natl Lab, Oak Ridge, TN USA |
推荐引用方式 GB/T 7714 | Broster, Lucas S.,Li, Juan,Wagner, Benjamin,et al. Spared behavioral repetition effects in Alzheimer's disease linked to an altered neural mechanism at posterior cortex[J]. JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY,2018,40(8):761-776. |
APA | Broster, Lucas S..,Li, Juan.,Wagner, Benjamin.,Smith, Charles D..,Jicha, Gregory A..,...&Jiang, Yang.(2018).Spared behavioral repetition effects in Alzheimer's disease linked to an altered neural mechanism at posterior cortex.JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY,40(8),761-776. |
MLA | Broster, Lucas S.,et al."Spared behavioral repetition effects in Alzheimer's disease linked to an altered neural mechanism at posterior cortex".JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY 40.8(2018):761-776. |
个性服务 |
查看访问统计 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论