A DRD2/ANNK1-COMT Interaction, Consisting of Functional Variants, Confers Risk of Post-traumatic Stress Disorder in Traumatized Chinese

doi:10.3389/fpsyt.2018.00170

CORC > 心理研究所 > 中国科学院心理研究所 > 中国科学院心理健康重点实验室

	A DRD2/ANNK1-COMT Interaction, Consisting of Functional Variants, Confers Risk of Post-traumatic Stress Disorder in Traumatized Chinese
	Zhang, Kunlin1,2,3 ; Wang, Li1,2,3 ; Cao, Chengqi 1,2,4; Li, Gen 1,2,3; Fang, Ruojiao 1,2,3; Liu, Ping 5; Luo, Shu 5; Zhang, Xiangyang1,2,3 ; Liberzon, Israel 6,7,8; Li Wang
刊名	FRONTIERS IN PSYCHIATRY
	2018-04-30
卷号	9 页码:1-9
关键词	post-traumatic stress disorder (PTSD) dopaminergic genes DRD2/ANNK1-COMT interaction modulate functional variants
ISSN号	1664-0640
DOI	10.3389/fpsyt.2018.00170
产权排序	1
文献子类	Article
英文摘要	Objective: Post-traumatic stress disorder (PTSD) is a trauma-and stress-related psychiatric syndrome that occurs after exposure to extraordinary stressors. The neurotransmitter dopamine (DA) plays important roles in neurobiological processes like reward and stress, and a link between PTSD and the dopaminergic system has been reported. Thus, the investigation of an association between PTSD and gene-gene interaction (epistasis) within dopaminergic genes could uncover the genetic basis of dopamine-related PTSD symptomatology and contribute to precision medicine.
WOS关键词	HUMAN GENETIC-VARIATION ; EARTHQUAKE SURVIVORS ; COMPLEX TRAITS ; RECEPTOR GENE ; DOPAMINE ; PTSD ; ASSOCIATION ; POLYMORPHISMS ; SYMPTOMS ; DEPRESSION
WOS研究方向	Psychiatry
语种	英语
WOS记录号	WOS:000431132500001
资助机构	External Cooperation Program of Chinese Academy of Sciences(153111KYSB20160036) ; National Natural Science Foundation of China(31471004 ; Key Project of Research Base of Humanities and Social Sciences of Ministry of Education(16JJD190006) ; 31470070 ; 31271099)
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/26200]
专题	心理研究所_中国科学院心理健康重点实验室
通讯作者	Li Wang
作者单位	1.Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Lab Traumat Stress Studies, Beijing, Peoples R China 2.Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Ctr Genet & BioMed Informat Res, Beijing, Peoples R China 3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 4.Shenzhen Univ, Shenzhen Key Lab Affect & Social Cognit Sci, Shenzhen, Peoples R China 5.Peoples Hosp Deyang, Deyang, Peoples R China 6.Univ Michigan, Dept Psychiat, Ann Arbor, MI 48109 USA 7.VA Ann Arbor Healthcare Syst, Mental Hlth Serv, Ann Arbor, MI USA 8.Univ Michigan, Dept Psychol, Ann Arbor, MI USA
推荐引用方式 GB/T 7714	Zhang, Kunlin,Wang, Li,Cao, Chengqi,et al. A DRD2/ANNK1-COMT Interaction, Consisting of Functional Variants, Confers Risk of Post-traumatic Stress Disorder in Traumatized Chinese[J]. FRONTIERS IN PSYCHIATRY,2018,9:1-9.
APA	Zhang, Kunlin.,Wang, Li.,Cao, Chengqi.,Li, Gen.,Fang, Ruojiao.,...&Li Wang.(2018).A DRD2/ANNK1-COMT Interaction, Consisting of Functional Variants, Confers Risk of Post-traumatic Stress Disorder in Traumatized Chinese.FRONTIERS IN PSYCHIATRY,9,1-9.
MLA	Zhang, Kunlin,et al."A DRD2/ANNK1-COMT Interaction, Consisting of Functional Variants, Confers Risk of Post-traumatic Stress Disorder in Traumatized Chinese".FRONTIERS IN PSYCHIATRY 9(2018):1-9.