Association of schizotypy with striatocortical functional connectivity and its asymmetry in healthy adults | |
Wang, Yi1![]() ![]() | |
刊名 | HUMAN BRAIN MAPPING
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2018 | |
卷号 | 39期号:1页码:288-299 |
关键词 | schizotypy functional magnetic resonance imaging resting state connectivity striatum lateralization |
ISSN号 | 1065-9471 |
DOI | 10.1002/hbm.23842 |
产权排序 | 1 |
文献子类 | Article |
英文摘要 | Altered striatocortical functional connectivity has been suggested to be a trait marker of schizophrenia spectrum disorders, including schizotypal personality. In the present study, we examined the association between schizotypal personality traits and striatocortical functional connectivity in a sample of healthy adults. The German version of the Schizotypal Personality Questionnaire was obtained from N=111 participants recruited from the general public. Resting-state functional magnetic resonance imaging scans were acquired at 3T. Six striatal seed regions in each hemisphere were defined and striatocortical resting-state functional connectivity (rsFC) as well as its lateralization indices was calculated. Regression analysis showed that schizotypy scores, especially from the positive dimension, were positively correlated with rsFC between ventral striatum and frontal cortex and negatively associated with rsFC between dorsal striatum and posterior cingulate. No significant associations were found between negative dimension schizotypy and striatocortical rsFC. We also found positive correlations between schizotypy total scores and lateralization index of right dorsal caudate and right rostral putamen. In conclusion, the present study extends previous evidence of altered striatocortical rsFC in the schizophrenia spectrum. The observed associations resemble in part the alterations observed in psychotic patients and their relatives, providing support for dimensionality from schizotypal personality to the clinical disorder. Hum Brain Mapp 39:288-299, 2018. (c) 2017 Wiley Periodicals, Inc. |
WOS关键词 | III-R CRITERIA ; PSYCHOMETRIC SCHIZOTYPY ; CORTICOSTRIATAL CIRCUITRY ; NEGATIVE SCHIZOTYPY ; BRAIN STRUCTURE ; EYE TRACKING ; CANNABIS USE ; SCHIZOPHRENIA ; PERSONALITY ; PSYCHOSIS |
WOS研究方向 | Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging |
语种 | 英语 |
WOS记录号 | WOS:000417282000019 |
资助机构 | DFG(Et 31/2-1) ; National Basic Research Programme of China(2016YFC0906402) ; Beijing Training Project for Leading Talents in ST(Z151100000315020) ; Beijing Municipal Science & Technology Commission(Z161100000216138) ; National Science Fund China(81571317 ; China Scholarship Council ; 31400884) |
内容类型 | 期刊论文 |
源URL | [http://ir.psych.ac.cn/handle/311026/25748] ![]() |
专题 | 心理研究所_中国科学院心理健康重点实验室 心理研究所_健康与遗传心理学研究室 |
通讯作者 | Ettinger, Ulrich; Chan, Raymond C K |
作者单位 | 1.CAS Key Lab Mental Hlth, Inst Psychol, Neuropsychol & Appl Cognit Neurosci NACN Lab, Beijing, Peoples R China 2.Univ Bonn, Dept Psychol, Kaiser Karl Ring 9, D-53111 Bonn, Germany 3.Univ Munich, Inst Clin Radiol, Munich, Germany 4.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Wang, Yi,Ettinger, Ulrich,Meindl, Thomas,et al. Association of schizotypy with striatocortical functional connectivity and its asymmetry in healthy adults[J]. HUMAN BRAIN MAPPING,2018,39(1):288-299. |
APA | Wang, Yi,Ettinger, Ulrich,Meindl, Thomas,Chan, Raymond C. K.,&Chan, Raymond C K.(2018).Association of schizotypy with striatocortical functional connectivity and its asymmetry in healthy adults.HUMAN BRAIN MAPPING,39(1),288-299. |
MLA | Wang, Yi,et al."Association of schizotypy with striatocortical functional connectivity and its asymmetry in healthy adults".HUMAN BRAIN MAPPING 39.1(2018):288-299. |
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