An overview of posttraumatic stress disorder genetic studies by analyzing and integrating genetic data into genetic database PTSDgene | |
Zhang, Kunlin1,2![]() ![]() ![]() ![]() ![]() | |
刊名 | NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
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2017-12-01 | |
卷号 | 83页码:647-656 |
关键词 | PTSD Genetic Gene-environment interaction Database |
ISSN号 | 0149-7634 |
DOI | 10.1016/j.neubiorev.2017.08.021 |
产权排序 | 1 |
文献子类 | Review |
英文摘要 | Posttraumatic stress disorder (PTSD) is a debilitating psychiatric syndrome with complex etiology. Studies aiming to explore genetic susceptibility and environmental triggers of PTSD have been increasing. However, the results are limited and highly heterogeneous. To understand the genetic study status of PTSD and explore more reliable candidates, we obtained 105 PTSD related genetic studies by comprehensively literature searching and filtering 1762 studies. Detailed phenotype and sample information for each study and association results for each genetic marker were extracted. Based on the extracted data, we reviewed the PTSD genetic research status and further conducted bioinformatics analyses for the genetic data. Our analyses summarized the landscape of PTSD genetic studies, identified the genes with most genetic evidence, discovered the biological function of the candidate variants/genes and enlarged the overall candidates for future investigations. All the data were stored in the PTSDgene database (http://ptsdgene.psych.ac.cn). We hope PTSDgene could be a platform for the rapid growth of PTSD genetic data and provide new insights into the pathogenesis of PTSD. |
WOS关键词 | GENOME-WIDE ASSOCIATION ; NATIONAL COMORBIDITY SURVEY ; DOMAIN CRITERIA RDOC ; LIFETIME PREVALENCE ; MENTAL-DISORDERS ; RECEPTOR GENE ; HPA-AXIS ; RISK ; ENVIRONMENT ; EXPRESSION |
WOS研究方向 | Behavioral Sciences ; Neurosciences & Neurology |
语种 | 英语 |
WOS记录号 | WOS:000419418700054 |
资助机构 | National Key Technology Research and Development Program of China(2013BAI08B02) ; National Natural Science Foundation of China(31271099 ; 31471004 ; 31401139) |
内容类型 | 期刊论文 |
源URL | [http://ir.psych.ac.cn/handle/311026/22300] ![]() |
专题 | 心理研究所_中国科学院心理健康重点实验室 |
通讯作者 | L. Wang; J. Wang |
作者单位 | 1.Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 3.Univ Amsterdam, Acad Med Ctr, Dept Psychiat, Diemen, Netherlands 4.Arq Psychotrauma Expert Grp, Diemen, Netherlands |
推荐引用方式 GB/T 7714 | Zhang, Kunlin,Qu, Susu,Chang, Suhua,et al. An overview of posttraumatic stress disorder genetic studies by analyzing and integrating genetic data into genetic database PTSDgene[J]. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS,2017,83:647-656. |
APA | Zhang, Kunlin.,Qu, Susu.,Chang, Suhua.,Li, Gen.,Cao, Chengqi.,...&J. Wang.(2017).An overview of posttraumatic stress disorder genetic studies by analyzing and integrating genetic data into genetic database PTSDgene.NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS,83,647-656. |
MLA | Zhang, Kunlin,et al."An overview of posttraumatic stress disorder genetic studies by analyzing and integrating genetic data into genetic database PTSDgene".NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS 83(2017):647-656. |
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