Linking Inter-Individual Variability in Functional Brain Connectivity to Cognitive Ability in Elderly Individuals | |
Li, Rui1,2; Yin, Shufei3; Zhu, Xinyi1,2; Ren, Weicong1,4; Yu, Jing1,5; Wang, Pengyun1,2; Zheng, Zhiwei1,2; Niu, Ya-Nan1,2; Huang, Xin1,2; Li, Juan1,2,6,7 | |
刊名 | FRONTIERS IN AGING NEUROSCIENCE |
2017-11-21 | |
卷号 | 9期号:0页码:1-13 |
关键词 | individual variability functional connectivity cognitive aging fMRI brain networks |
ISSN号 | 1663-4365 |
DOI | 10.3389/fnagi.2017.00385 |
产权排序 | 1 |
文献子类 | Article |
英文摘要 | Increasing evidence suggests that functional brain connectivity is an important determinant of cognitive aging. However, the fundamental concept of inter-individual variations in functional connectivity in older individuals is not yet completely understood. It is essential to evaluate the extent to which inter-individual variability in connectivity impacts cognitive performance at an older age. In the current study, we aimed to characterize individual variability of functional connectivity in the elderly and to examine its significance to individual cognition. We mapped inter-individual variability of functional connectivity by analyzing whole-brain functional connectivity magnetic resonance imaging data obtained from a large sample of cognitively normal older adults. Our results demonstrated a gradual increase in variability in primary regions of the visual, sensorimotor, and auditory networks to specific subcortical structures, particularly the hippocampal formation, and the prefrontal and parietal cortices, which largely constitute the default mode and fronto-parietal networks, to the cerebellum. Further, the inter-individual variability of the functional connectivity correlated significantly with the degree of cognitive relevance. Regions with greater connectivity variability demonstrated more connections that correlated with cognitive performance. These results also underscored the crucial function of the long-range and inter-network connections in individual cognition. Thus, individual connectivity-cognition variability mapping findings may provide important information for future research on cognitive aging and neurocognitive diseases. |
WOS关键词 | RESTING-STATE FMRI ; ALZHEIMERS-DISEASE ; NETWORK CONNECTIVITY ; CORTICAL NETWORKS ; HUMAN CEREBELLUM ; MOTION ARTIFACT ; WHITE-MATTER ; AGING BRAIN ; AGE ; NEUROSCIENCE |
WOS研究方向 | Geriatrics & Gerontology ; Neurosciences & Neurology |
语种 | 英语 |
WOS记录号 | WOS:000415820600001 |
资助机构 | National Natural Science Foundation of China(31671157 ; Beijing Municipal Science and Technology Commission(Z171100000117006) ; Pioneer Initiative of the Chinese Academy of Sciences, Feature Institutes Program(TSS-2015-06) ; National Key Research and Development Program of China(2016YFC1305904) ; CAS Key Laboratory of Mental Health, Institute of Psychology(KLMH2014ZK02 ; 31470998 ; KLMH2014ZG03) ; 61673374 ; 31271108 ; 31200847 ; 31600904) |
内容类型 | 期刊论文 |
源URL | [http://ir.psych.ac.cn/handle/311026/22012] |
专题 | 心理研究所_中国科学院心理健康重点实验室 |
通讯作者 | Li, Juan |
作者单位 | 1.Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 3.Hubei Univ, Dept Psychol, Fac Educ, Wuhan, Hubei, Peoples R China 4.Hebei Normal Univ, Dept Educ, Shijiazhuang, Hebei, Peoples R China 5.Southwest Univ, Fac Psychol, Chongqing, Peoples R China 6.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing, Peoples R China 7.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Li, Rui,Yin, Shufei,Zhu, Xinyi,et al. Linking Inter-Individual Variability in Functional Brain Connectivity to Cognitive Ability in Elderly Individuals[J]. FRONTIERS IN AGING NEUROSCIENCE,2017,9(0):1-13. |
APA | Li, Rui.,Yin, Shufei.,Zhu, Xinyi.,Ren, Weicong.,Yu, Jing.,...&Li, Juan.(2017).Linking Inter-Individual Variability in Functional Brain Connectivity to Cognitive Ability in Elderly Individuals.FRONTIERS IN AGING NEUROSCIENCE,9(0),1-13. |
MLA | Li, Rui,et al."Linking Inter-Individual Variability in Functional Brain Connectivity to Cognitive Ability in Elderly Individuals".FRONTIERS IN AGING NEUROSCIENCE 9.0(2017):1-13. |
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