Effect of 5-aza-2-deoxycytidine microinjecting into hippocampus and prelimbic cortex on acquisition and retrieval of cocaine-induced place preference in C57BL/6 mice | |
Han, Jin1,2; Li, Yonghui1![]() ![]() ![]() ![]() ![]() | |
刊名 | EUROPEAN JOURNAL OF PHARMACOLOGY
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2010-09-10 | |
卷号 | 642期号:1-3页码:93-98 |
关键词 | DNA methylation Hippocampus Prelimbic cortex Cocaine Conditioned place preference |
ISSN号 | 0014-2999 |
DOI | 10.1016/j.ejphar.2010.05.050 |
产权排序 | 1 |
文献子类 | Article |
英文摘要 | The long lasting addiction-related abnormal memory is one of the most important foundations for relapse. DNA methylation may be a possible mechanism for persistence of such memory. Here we injected the DNA methyltransferases (DNMTs) inhibitor, 5-aza-2-deoxycytidine (5-aza) into hippocampus CA1 area and prelimbic cortex during the stages of acquisition and expression of cocaine-induced place preference in C57BL/6 mice. Results showed that in CA1 DNA methylation inhibitors could restrain acquisition but had no impact on expression of the cocaine-induced conditioned place preference (CPP). On the contrary, in prelimbic cortex, 5-aza had no effect on acquisition but blocked expression. Our results indicated that DNA methylation in hippocampus is required for learning; while DNA methylation in prelimbic cortex is necessary for memory retrieval. The present finding is consistent with the role of the hippocampus as a structure contributing to cocaine-induced memory acquisition, and prelimbic cortex, a part of prefrontal cortex as an area responsible for cocaine-induced memory retrieval. In conclusion, DNA methylation does play an important role in drug-induced learning and memory although the detailed effect still calls for further research. (C) 2010 Elsevier B.V. All rights reserved. |
学科主题 | 医学心理学 |
资助项目 | 一室隋南课题组 |
语种 | 英语 |
WOS记录号 | WOS:000280681500012 |
公开日期 | 2011-11-14 |
内容类型 | 期刊论文 |
源URL | [http://ir.psych.ac.cn/handle/311026/7036] ![]() |
专题 | 心理研究所_中国科学院心理研究所回溯数据库(1956-2010) |
通讯作者 | Sui, Nan |
作者单位 | 1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100101, Peoples R China |
推荐引用方式 GB/T 7714 | Han, Jin,Li, Yonghui,Wang, Dongmei,et al. Effect of 5-aza-2-deoxycytidine microinjecting into hippocampus and prelimbic cortex on acquisition and retrieval of cocaine-induced place preference in C57BL/6 mice[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2010,642(1-3):93-98. |
APA | Han, Jin,Li, Yonghui,Wang, Dongmei,Wei, Chuguang,Yang, Xiaoyan,&Sui, Nan.(2010).Effect of 5-aza-2-deoxycytidine microinjecting into hippocampus and prelimbic cortex on acquisition and retrieval of cocaine-induced place preference in C57BL/6 mice.EUROPEAN JOURNAL OF PHARMACOLOGY,642(1-3),93-98. |
MLA | Han, Jin,et al."Effect of 5-aza-2-deoxycytidine microinjecting into hippocampus and prelimbic cortex on acquisition and retrieval of cocaine-induced place preference in C57BL/6 mice".EUROPEAN JOURNAL OF PHARMACOLOGY 642.1-3(2010):93-98. |
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