Social crowding sensitizes high-responding rats to psychomotor-stimulant effects of morphine

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	Social crowding sensitizes high-responding rats to psychomotor-stimulant effects of morphine
	Zheng, XG; Li, YH; Luo, XJ; Xiao, L; Wang, DM; Liu, J; Yang, XY; Sui, N; N. Sui
刊名	PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
	2004-10-01
卷号	79 期号:2 页码:213-218
关键词	susceptibility morphine psychomotor sensitization social crowding individual differences
ISSN号	0091-3057
文献子类	Article
英文摘要	Large individual differences have been identified toward varied addictive effects as evidenced in self-administration, place conditioning, and psychomotor stimulation paradiams, which have been primarily attributed to the role of congenital factors. However, it remains unknown whether environmental factors, like extraneous social stress events, could distinctively modulate animals with differentiated biobehavioral traits, such as rats with higher motor activity (high responder, HR) developed in a novel environment and their counterparts, LR (low responder) rats. In the present study, the influence of social crowding procedure upon morphine psychomotor effect was investigated. Moreover, the roles social stress played, respectively, on HRs and LRs were explored based on previous observation that HRs not only responded more to drugs but also to stress. Our results revealed that social crowding procedure could sensitize morphine psychomotor effect as a whole, and this effect was only evident for HR but not LR rats. The individual differences toward morphine psychornotor effects was indiscernible in rats housed in normal social conditions and only turned out to be significant under stress conditions. Given the fact that the occurrence of human addictive behavior usually happens within social environment permeated with various stress factors, the genetic and environmental elements may collaboratively contribute to the ultimate susceptibility of drug-prone individuals.; Large individual differences have been identified toward varied addictive effects as evidenced in self-administration, place conditioning, and psychomotor stimulation paradiams, which have been primarily attributed to the role of congenital factors. However, it remains unknown whether environmental factors, like extraneous social stress events, could distinctively modulate animals with differentiated biobehavioral traits, such as rats with higher motor activity (high responder, HR) developed in a novel environment and their counterparts, LR (low responder) rats. In the present study, the influence of social crowding procedure upon morphine psychomotor effect was investigated. Moreover, the roles social stress played, respectively, on HRs and LRs were explored based on previous observation that HRs not only responded more to drugs but also to stress. Our results revealed that social crowding procedure could sensitize morphine psychomotor effect as a whole, and this effect was only evident for HR but not LR rats. The individual differences toward morphine psychornotor effects was indiscernible in rats housed in normal social conditions and only turned out to be significant under stress conditions. Given the fact that the occurrence of human addictive behavior usually happens within social environment permeated with various stress factors, the genetic and environmental elements may collaboratively contribute to the ultimate susceptibility of drug-prone individuals. (C) 2004 Elsevier Inc. All rights reserved.
学科主题	医学心理学
语种	英语
WOS记录号	WOS:000225045300002
公开日期	2011-08-22
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/5692]
专题	心理研究所_中国科学院心理研究所回溯数据库(1956-2010)
通讯作者	N. Sui
作者单位	Acad Sinica, Inst Psychol, Key Lab Mental Hlth, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Zheng, XG,Li, YH,Luo, XJ,et al. Social crowding sensitizes high-responding rats to psychomotor-stimulant effects of morphine[J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,2004,79(2):213-218.
APA	Zheng, XG.,Li, YH.,Luo, XJ.,Xiao, L.,Wang, DM.,...&N. Sui.(2004).Social crowding sensitizes high-responding rats to psychomotor-stimulant effects of morphine.PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,79(2),213-218.
MLA	Zheng, XG,et al."Social crowding sensitizes high-responding rats to psychomotor-stimulant effects of morphine".PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 79.2(2004):213-218.