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	Opposite effects of MK-801 on the expression of food and morphine-induced conditioned place preference in rats
	Li, YH; Zheng, XG; Bai, YJ; Yang, XY; Sui, N; N. Sui
刊名	JOURNAL OF PSYCHOPHARMACOLOGY
	2006
卷号	20期号:1页码:40-46
关键词	MK-801 morphine food expression of CPP craving
ISSN号	0269-8811
文献子类	Article
英文摘要	Behavioural studies have provided strong evidence for common substrates in the rewards of natural and addictive substances, but it is still unclear whether there is a common glutamatergic NMDA receptor mechanism involved in the processing of reward for both. The present study was designed to investigate the effects of MK-801 (0.1mg/kg) on the expression of place preference conditioned with food and morphine (5.0mg/kg) in rats. The data indicates that MK-801 potentiates the expression of food-induced conditioned place preference (CPP) but retards that of morphine CPP. It also demonstrates that the opposite effects of MK-801 on food and morphine CPP expression were caused neither by hyperactivity nor by the impairment of memory retrieval. These results suggest that MK-801 enhances food craving and inhibits morphine craving in rats, and that the roles of glutamatergic NMDA receptor mechanisms in the reward processing of natural reinforcers and addictive drugs may be dissociable.; Behavioural studies have provided strong evidence for common substrates in the rewards of natural and addictive substances, but it is still unclear whether there is a common glutamatergic NMDA receptor mechanism involved in the processing of reward for both. The present study was designed to investigate the effects of MK-801 (0.1 mg/kg) on the expression of place preference conditioned with food and morphine (5.0 mg/kg) in rats. The data indicates that MK-801 potentiates the expression of food-induced conditioned place preference (CPP) but retards that of morphine CPP. It also demonstrates that the opposite effects of MK-801 on food and morphine CPP expression were caused neither by hyperactivity nor by the impairment of memory retrieval. These results suggest that MK-801 enhances food craving and inhibits morphine craving in rats, and that the roles of glutamatergic NMDA receptor mechanisms in the reward processing of natural reinforcers and addictive drugs may be dissociable.
学科主题	医学心理学
语种	英语
WOS记录号	WOS:000235451200006
公开日期	2011-08-22
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/5602]
专题	心理研究所_中国科学院心理研究所回溯数据库(1956-2010)
通讯作者	N. Sui
作者单位	1.Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China 2.Chinese Acad Sci, Lab Mental Hlth, Beijing, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Li, YH,Zheng, XG,Bai, YJ,et al. Opposite effects of MK-801 on the expression of food and morphine-induced conditioned place preference in rats[J]. JOURNAL OF PSYCHOPHARMACOLOGY,2006,20(1):40-46.
APA	Li, YH,Zheng, XG,Bai, YJ,Yang, XY,Sui, N,&N. Sui.(2006).Opposite effects of MK-801 on the expression of food and morphine-induced conditioned place preference in rats.JOURNAL OF PSYCHOPHARMACOLOGY,20(1),40-46.
MLA	Li, YH,et al."Opposite effects of MK-801 on the expression of food and morphine-induced conditioned place preference in rats".JOURNAL OF PSYCHOPHARMACOLOGY 20.1(2006):40-46.

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