Hypoglycemic Properties of Oxovanadium (IV) Coordination Compounds with Carboxymethyl-Carrageenan and Carboxymethyl-Chitosan in Alloxan-Induced Diabetic Mice | |
Zhang, Hongyu2; Yi, Yuetao1![]() ![]() ![]() ![]() | |
刊名 | EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
![]() |
2011 | |
卷号 | .页码:1-7 |
关键词 | Vanadyl Sulfate Insulin Sensitivity Blood-glucose In-vivo Rats Complexes Mellitus Oxidation Systems |
ISSN号 | 1741-427X |
DOI | 10.1155/2011/691067 |
通讯作者 | Yi, YT (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Biol Resources Lab, Yantai 264003, Peoples R China |
产权排序 | [Yi, Yuetao; Qin, Song] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Biol Resources Lab, Yantai 264003, Peoples R China; [Zhang, Hongyu] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
文献子类 | Article |
英文摘要 | In order to avoid low absorption, incorporation, and undesirable side effects of inorganic oxovanadium compounds, the antidiabetic activities of organic oxovanadium (IV) compounds in alloxan-induced diabetic mice were investigated. Vanadyl carboxymethyl carrageenan (VOCCA) and vanadyl carboxymethyl chitosan (VOCCH) were synthesized and administrated through intragastric administration in different doses for 20 days in alloxan-induced diabetic mice. Glibenclamide was administrated as the positive control. Our results showed that low-dose group, middle-dose group, and high-dose group of VOCCA and VOCCH could significantly reduce the levels of blood glucose (P < 0.05) compared with untreated group, but not in normal mice. Besides, high-dose groups of VOCCA and VOCCH exhibited more significant hypoglycemic activities (P < 0.01). After treated with VOCCH, the oral glucose tolerance of high-dose group of VOCCH was improved compared with model control group (P < 0.05). |
学科主题 | Integrative & Complementary Medicine |
URL标识 | 查看原文 |
WOS关键词 | VANADYL SULFATE ; INSULIN SENSITIVITY ; BLOOD-GLUCOSE ; IN-VIVO ; RATS ; COMPLEXES ; MELLITUS ; OXIDATION ; SYSTEMS |
WOS研究方向 | Integrative & Complementary Medicine |
语种 | 英语 |
WOS记录号 | WOS:000293527800001 |
资助机构 | Chinese Academy of Sciences[KZCX2-YW-225]; Science & Technology Development Plan of Shandong Province[2010GSF10208]; CAS/SAFEA ; Chinese Academy of Sciences KZCX2-YW-225 ; Science & Technology Development Plan of Shandong Province 2010GSF10208 ; CAS/SAFEA |
公开日期 | 2012-03-06 |
内容类型 | 期刊论文 |
源URL | [http://ir.yic.ac.cn/handle/133337/5353] ![]() |
专题 | 烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室 |
作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Biol Resources Lab, Yantai 264003, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
推荐引用方式 GB/T 7714 | Zhang, Hongyu,Yi, Yuetao,Feng, Dawei,et al. Hypoglycemic Properties of Oxovanadium (IV) Coordination Compounds with Carboxymethyl-Carrageenan and Carboxymethyl-Chitosan in Alloxan-Induced Diabetic Mice[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2011,.:1-7. |
APA | Zhang, Hongyu,Yi, Yuetao,Feng, Dawei,Wang, Yipeng,&Qin, Song.(2011).Hypoglycemic Properties of Oxovanadium (IV) Coordination Compounds with Carboxymethyl-Carrageenan and Carboxymethyl-Chitosan in Alloxan-Induced Diabetic Mice.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,.,1-7. |
MLA | Zhang, Hongyu,et al."Hypoglycemic Properties of Oxovanadium (IV) Coordination Compounds with Carboxymethyl-Carrageenan and Carboxymethyl-Chitosan in Alloxan-Induced Diabetic Mice".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE .(2011):1-7. |
个性服务 |
查看访问统计 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论