Bioactive Pyridone Alkaloids from a Deep-Sea-Derived Fungus Arthrinium sp UJNMF0008

CORC > 南海海洋研究所 > 中国科学院南海海洋研究所 > 中科院海洋生物资源可持续利用重点实验室

	Bioactive Pyridone Alkaloids from a Deep-Sea-Derived Fungus Arthrinium sp UJNMF0008
	Zhang, H; Zhang, YY; Yu, JH; Zhu, KK; Bao, J; Wang, YY; Jiang, CS; Zhang, XY; Zhang, Y; Zhai, HJ
刊名	MARINE DRUGS
	2018
卷号	16 期号:5 页码:-174
通讯作者	bio_baoj@ujn.edu.cn ; zhai18363005528@163.com ; hkhhh.k@163.com ; yujinhai12@sina.com ; zhangyun@scsio.ac.cn ; bio_wangyy@ujn.edu.cn ; jiangchengshi-20@163.com ; zhangxiaoyong@scau.edu.cn ; zhangyun@scsio.ac.cn ; bio_zhangh@ujn.edu.cn
英文摘要	Eight new 4-hydroxy-2-pyridone alkaloids arthpyrones D-K (1-8), along with two known analogues apiosporamide (9) and arthpyrone B (10), were isolated from a deep-sea-derived fungus Arthrinium sp. UJNMF0008. The structures of the isolated compounds were elucidated on the basis of spectroscopic methods with that of 1 being established by chemical transformation and X-ray diffraction analysis. Compounds 1 and 2 bore an ester functionality linking the pyridone and decalin moieties first reported in this class of metabolites, while 3 and 4 incorporated a rare natural hexa- or tetrahydrobenzofuro[3,2-c]pyridin-3(2H)-one motif. Compounds 3-6 and 9 exhibited moderate to significant antibacterial activity against Mycobacterium smegmatis and Staphylococcus aureus with IC50 values ranging from 1.66-42.8 M, while 9 displayed cytotoxicity against two human osteosarcoma cell lines (U2OS and MG63) with IC50 values of 19.3 and 11.7 M, respectively.
学科主题	Pharmacology & Pharmacy
关键词[WOS]	Arthrinium ; pyridone alkaloid ; antibacterial activity ; cytotoxicity
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/16951]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
推荐引用方式 GB/T 7714	Zhang, H,Zhang, YY,Yu, JH,et al. Bioactive Pyridone Alkaloids from a Deep-Sea-Derived Fungus Arthrinium sp UJNMF0008[J]. MARINE DRUGS,2018,16(5):-174.
APA	Zhang, H.,Zhang, YY.,Yu, JH.,Zhu, KK.,Bao, J.,...&Zhai, HJ.(2018).Bioactive Pyridone Alkaloids from a Deep-Sea-Derived Fungus Arthrinium sp UJNMF0008.MARINE DRUGS,16(5),-174.
MLA	Zhang, H,et al."Bioactive Pyridone Alkaloids from a Deep-Sea-Derived Fungus Arthrinium sp UJNMF0008".MARINE DRUGS 16.5(2018):-174.