Spatial function of the oxidative DNA damage response in radiation induced bystander effects in intra- and inter-system of Caenorhabditis elegans | |
Li, Qingqing1,2; Shi, Jue1,2; Chen, Lianyun1; Zhan, Furu1; Yuan, Hang1; Wang, Jun1; Xu, An1; Wu, Lijun1,2,3 | |
刊名 | ONCOTARGET |
2017-08-01 | |
卷号 | 8期号:31页码:51253-51263 |
关键词 | C. Elegans Ddr Tissue Specific Rnai Ros Ribe |
DOI | 10.18632/oncotarget.17229 |
文献子类 | Article |
英文摘要 | Though the signaling events involved in radiation induced bystander effects (RIBE) have been investigated both in vitro and in vivo, the spatial function of these communications, especially the related signaling pathways, is not fully elucidated. In the current study, significant increases of DNA damage were clearly observed in C. elegans germline upon irradiation to both intra-system of posterior pharynx and intersystem of vulva, in which more severe damage, even to F1 generation worms, was shown for vulva irradiation. Spatial function assay indicated the DDR key components of mrt-2/hus-1/cep-1/ced-4 were indispensable in germ cells for both sites irradiation, while those components in somatic cells were either not (cep-1/ced-4) or partially (mrt-2/hus-1) required to promote apoptosis. Moreover, production of reactive oxygen species (ROS) indicated by the superoxide dismutase expression and the unfolded protein response of the mitochondria was found systemically involved in the initiation of these processes for both two site irradiation. These results will give a better understanding of the RIBE mechanisms in vivo, and invaluable to assess the clinical relevance to radiotherapy. |
WOS关键词 | CELL-CYCLE ARREST ; IONIZING-RADIATION ; C. ELEGANS ; IN-VIVO ; INTERCELLULAR COMMUNICATION ; MICROBEAM IRRADIATION ; GENOMIC INSTABILITY ; PARTICLE MICROBEAM ; INDUCED APOPTOSIS ; HUMAN FIBROBLASTS |
WOS研究方向 | Oncology ; Cell Biology |
语种 | 英语 |
WOS记录号 | WOS:000406717200086 |
资助机构 | National Natural Science Foundation of China(31470829 ; National Natural Science Foundation of China(31470829 ; National Natural Science Foundation of China(31470829 ; National Natural Science Foundation of China(31470829 ; National Natural Science Foundation of China(31470829 ; National Natural Science Foundation of China(31470829 ; National Natural Science Foundation of China(31470829 ; National Natural Science Foundation of China(31470829 ; International Partnership Program of Chinese Academy of Sciences(116134KYSB20160084) ; International Partnership Program of Chinese Academy of Sciences(116134KYSB20160084) ; International Partnership Program of Chinese Academy of Sciences(116134KYSB20160084) ; International Partnership Program of Chinese Academy of Sciences(116134KYSB20160084) ; International Partnership Program of Chinese Academy of Sciences(116134KYSB20160084) ; International Partnership Program of Chinese Academy of Sciences(116134KYSB20160084) ; International Partnership Program of Chinese Academy of Sciences(116134KYSB20160084) ; International Partnership Program of Chinese Academy of Sciences(116134KYSB20160084) ; CAS/SAFEA International Partnership Program for Creative Research Teams ; CAS/SAFEA International Partnership Program for Creative Research Teams ; CAS/SAFEA International Partnership Program for Creative Research Teams ; CAS/SAFEA International Partnership Program for Creative Research Teams ; CAS/SAFEA International Partnership Program for Creative Research Teams ; CAS/SAFEA International Partnership Program for Creative Research Teams ; CAS/SAFEA International Partnership Program for Creative Research Teams ; CAS/SAFEA International Partnership Program for Creative Research Teams ; National Basic Research 973 Program(2014CB932002) ; National Basic Research 973 Program(2014CB932002) ; National Basic Research 973 Program(2014CB932002) ; National Basic Research 973 Program(2014CB932002) ; National Basic Research 973 Program(2014CB932002) ; National Basic Research 973 Program(2014CB932002) ; National Basic Research 973 Program(2014CB932002) ; National Basic Research 973 Program(2014CB932002) ; 81273004 ; 81273004 ; 81273004 ; 81273004 ; 81273004 ; 81273004 ; 81273004 ; 81273004 ; 21407002) ; 21407002) ; 21407002) ; 21407002) ; 21407002) ; 21407002) ; 21407002) ; 21407002) ; National Natural Science Foundation of China(31470829 ; National Natural Science Foundation of China(31470829 ; National Natural Science Foundation of China(31470829 ; National Natural Science Foundation of China(31470829 ; National Natural Science Foundation of China(31470829 ; National Natural Science Foundation of China(31470829 ; National Natural Science Foundation of China(31470829 ; National Natural Science Foundation of China(31470829 ; International Partnership Program of Chinese Academy of Sciences(116134KYSB20160084) ; International Partnership Program of Chinese Academy of Sciences(116134KYSB20160084) ; International Partnership Program of Chinese Academy of Sciences(116134KYSB20160084) ; International Partnership Program of Chinese Academy of Sciences(116134KYSB20160084) ; International Partnership Program of Chinese Academy of Sciences(116134KYSB20160084) ; International Partnership Program of Chinese Academy of Sciences(116134KYSB20160084) ; International Partnership Program of Chinese Academy of Sciences(116134KYSB20160084) ; International Partnership Program of Chinese Academy of Sciences(116134KYSB20160084) ; CAS/SAFEA International Partnership Program for Creative Research Teams ; CAS/SAFEA International Partnership Program for Creative Research Teams ; CAS/SAFEA International Partnership Program for Creative Research Teams ; CAS/SAFEA International Partnership Program for Creative Research Teams ; CAS/SAFEA International Partnership Program for Creative Research Teams ; CAS/SAFEA International Partnership Program for Creative Research Teams ; CAS/SAFEA International Partnership Program for Creative Research Teams ; CAS/SAFEA International Partnership Program for Creative Research Teams ; National Basic Research 973 Program(2014CB932002) ; National Basic Research 973 Program(2014CB932002) ; National Basic Research 973 Program(2014CB932002) ; National Basic Research 973 Program(2014CB932002) ; National Basic Research 973 Program(2014CB932002) ; National Basic Research 973 Program(2014CB932002) ; National Basic Research 973 Program(2014CB932002) ; National Basic Research 973 Program(2014CB932002) ; 81273004 ; 81273004 ; 81273004 ; 81273004 ; 81273004 ; 81273004 ; 81273004 ; 81273004 ; 21407002) ; 21407002) ; 21407002) ; 21407002) ; 21407002) ; 21407002) ; 21407002) ; 21407002) |
内容类型 | 期刊论文 |
源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/33606] |
专题 | 合肥物质科学研究院_技术生物与农业工程研究所 |
作者单位 | 1.Chinese Acad Sci, Key Lab Ion Beam Bioengn, Hefei Inst Phys Sci, Hefei 230031, Anhui, Peoples R China 2.Univ Sci & Technol China, Hefei 230026, Anhui, Peoples R China 3.Key Lab Environm Toxicol & Pollut Control Technol, Hefei 230031, Anhui, Peoples R China |
推荐引用方式 GB/T 7714 | Li, Qingqing,Shi, Jue,Chen, Lianyun,et al. Spatial function of the oxidative DNA damage response in radiation induced bystander effects in intra- and inter-system of Caenorhabditis elegans[J]. ONCOTARGET,2017,8(31):51253-51263. |
APA | Li, Qingqing.,Shi, Jue.,Chen, Lianyun.,Zhan, Furu.,Yuan, Hang.,...&Wu, Lijun.(2017).Spatial function of the oxidative DNA damage response in radiation induced bystander effects in intra- and inter-system of Caenorhabditis elegans.ONCOTARGET,8(31),51253-51263. |
MLA | Li, Qingqing,et al."Spatial function of the oxidative DNA damage response in radiation induced bystander effects in intra- and inter-system of Caenorhabditis elegans".ONCOTARGET 8.31(2017):51253-51263. |
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