Porcine enterocyte protein Btnl5 negatively regulates NF-kappa B pathway by interfering p65 nuclear translocation

doi:10.1016/j.gene.2017.11.070

	Porcine enterocyte protein Btnl5 negatively regulates NF-kappa B pathway by interfering p65 nuclear translocation
	Bao, Qi 2,3,4,5; Li, Chong 1; Xu, Chongfeng 4; Zhang, Ruiying 4; Zhao, Kai 2,3; Duan, Ziyuan 4
刊名	GENE
	2018-03-10
卷号	646 页码:47-55
关键词	Btnl5 Iecs Nf-kappa b Immune Regulation Interacting Proteins
DOI	10.1016/j.gene.2017.11.070
英文摘要	Porcine butyrophilin-like 5 (Btnl5) is a novel member of the butyrophilin family, which consists of immune regulators. The expression pattern and the function of this gene remain unclear. In this study, Btnl5 is identified as a negative regulator of the NF-kappa B pathway. Our study indicates that Btnl5 is mainly expressed in intestinal epithelial cells (IECs) and expressed in membrane systems. Btnl5 inhibits MyD88-mediated activation of the NF-kappa B pathway. Btnl5 interacts with TNF receptor-associated factor 2 (TRAF2) and transcription factor p65. Besides, Btnl5 inhibits p65-mediated activation of the NF-kappa B pathway and inhibits nuclear translocation of p65. These results suggest that Btnl5 may inhibit NF-kappa B pathway through binding and interfere nuclear translocation of p65.
语种	英语
WOS记录号	WOS:000425080000007
内容类型	期刊论文
源URL	[http://ir.nwipb.ac.cn/handle/363003/13334]
专题	西北高原生物研究所_中国科学院西北高原生物研究所
作者单位	1.Chinese Acad Sci, Inst Biophys, Core Facil Prot Res, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Adaptat & Evolut Plateau Biota, Xining 810001, Qinghai, Peoples R China 3.Chinese Acad Sci, Northwest Inst Plateau Biol, Lab Plateau Fish Evolutionary & Funct Genom, Xining 810001, Qinghai, Peoples R China 4.Chinese Acad Sci, Genet Resource Ctr, Inst Genet & Dev Biol, Beijing 100101, Peoples R China 5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Bao, Qi,Li, Chong,Xu, Chongfeng,et al. Porcine enterocyte protein Btnl5 negatively regulates NF-kappa B pathway by interfering p65 nuclear translocation[J]. GENE,2018,646:47-55.
APA	Bao, Qi,Li, Chong,Xu, Chongfeng,Zhang, Ruiying,Zhao, Kai,&Duan, Ziyuan.(2018).Porcine enterocyte protein Btnl5 negatively regulates NF-kappa B pathway by interfering p65 nuclear translocation.GENE,646,47-55.
MLA	Bao, Qi,et al."Porcine enterocyte protein Btnl5 negatively regulates NF-kappa B pathway by interfering p65 nuclear translocation".GENE 646(2018):47-55.