Brown adipose tissue transplantation ameliorates polycystic ovary syndrome

doi:10.1073/pnas.1523236113

CORC > 合肥物质科学研究院 > 中国科学院合肥物质科学研究院 > 中科院强磁场科学中心

	Brown adipose tissue transplantation ameliorates polycystic ovary syndrome
	Yuan, Xiaoxue 1,2; Hu, Tao 1,2; Zhao, Han 3,4; Huang, Yuanyuan 1; Ye, Rongcai 1,2; Lin, Jun 1,2; Zhang, Chuanhai 1,5; Zhang, Hanlin 1; Wei, Gang 1,2; Zhou, Huiqiao 1,2
刊名	PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
	2016-03-08
卷号	113 期号:10 页码:2708-2713
关键词	Brown Adipose Tissue Transplantation Ameliorates Pcos Adiponectin
DOI	10.1073/pnas.1523236113
文献子类	Article
英文摘要	Polycystic ovary syndrome (PCOS), which is characterized by anovulation, hyperandrogenism, and polycystic ovaries, is a complex endocrinopathy. Because the cause of PCOS at the molecular level is largely unknown, there is no cure or specific treatment for PCOS. Here, we show that transplantation of brown adipose tissue (BAT) reversed anovulation, hyperandrogenism, and polycystic ovaries in a dehydroepiandrosterone (DHEA)-induced PCOS rat. BAT transplantation into a PCOS rat significantly stabilized menstrual irregularity and improved systemic insulin sensitivity up to a normal level, which was not shown in a sham-operated or muscle-transplanted PCOS rat. Moreover, BAT transplantation, not sham operation or muscle transplantation, surprisingly improved fertility in PCOS rats. Interestingly, BAT transplantation activated endogenous BAT and thereby increased the circulating level of adiponectin, which plays a prominent role in whole-body energy metabolism and ovarian physiology. Consistent with BAT transplantation, administration of adiponectin protein dramatically rescued DHEA-induced PCOS phenotypes. These results highlight that endogenous BAT activity is closely related to the development of PCOS phenotypes and that BAT activation might be a promising therapeutic option for the treatment of PCOS.
WOS关键词	INSULIN-RESISTANCE ; PREVALENCE ; MICE ; THERMOGENESIS ; DIAGNOSIS ; HUMANS ; FEATURES ; OBESITY ; WOMEN ; MASS
WOS研究方向	Science & Technology - Other Topics
语种	英语
WOS记录号	WOS:000372013300045
资助机构	Ministry of Science and Technology of China(2012CB944701 ; Ministry of Science and Technology of China(2012CB944701 ; Ministry of Science and Technology of China(2012CB944701 ; Ministry of Science and Technology of China(2012CB944701 ; Strategic Priority Research Program(XDB13030000) ; Strategic Priority Research Program(XDB13030000) ; Strategic Priority Research Program(XDB13030000) ; Strategic Priority Research Program(XDB13030000) ; Key Research Program(KJZD-EW-L01-3) ; Key Research Program(KJZD-EW-L01-3) ; Key Research Program(KJZD-EW-L01-3) ; Key Research Program(KJZD-EW-L01-3) ; One Hundred Talents Program of the Chinese Academy of Sciences ; One Hundred Talents Program of the Chinese Academy of Sciences ; One Hundred Talents Program of the Chinese Academy of Sciences ; One Hundred Talents Program of the Chinese Academy of Sciences ; National Natural Science Foundation\ of China(31171131 ; National Natural Science Foundation\ of China(31171131 ; National Natural Science Foundation\ of China(31171131 ; National Natural Science Foundation\ of China(31171131 ; National Natural Science Foundation of China(81430029 ; National Natural Science Foundation of China(81430029 ; National Natural Science Foundation of China(81430029 ; National Natural Science Foundation of China(81430029 ; 2012CB944700) ; 2012CB944700) ; 2012CB944700) ; 2012CB944700) ; 81370951) ; 81370951) ; 81370951) ; 81370951) ; 81490743 ; 81490743 ; 81490743 ; 81490743 ; 31371453 ; 31371453 ; 31371453 ; 31371453 ; 31571548) ; 31571548) ; 31571548) ; 31571548) ; Ministry of Science and Technology of China(2012CB944701 ; Ministry of Science and Technology of China(2012CB944701 ; Ministry of Science and Technology of China(2012CB944701 ; Ministry of Science and Technology of China(2012CB944701 ; Strategic Priority Research Program(XDB13030000) ; Strategic Priority Research Program(XDB13030000) ; Strategic Priority Research Program(XDB13030000) ; Strategic Priority Research Program(XDB13030000) ; Key Research Program(KJZD-EW-L01-3) ; Key Research Program(KJZD-EW-L01-3) ; Key Research Program(KJZD-EW-L01-3) ; Key Research Program(KJZD-EW-L01-3) ; One Hundred Talents Program of the Chinese Academy of Sciences ; One Hundred Talents Program of the Chinese Academy of Sciences ; One Hundred Talents Program of the Chinese Academy of Sciences ; One Hundred Talents Program of the Chinese Academy of Sciences ; National Natural Science Foundation\ of China(31171131 ; National Natural Science Foundation\ of China(31171131 ; National Natural Science Foundation\ of China(31171131 ; National Natural Science Foundation\ of China(31171131 ; National Natural Science Foundation of China(81430029 ; National Natural Science Foundation of China(81430029 ; National Natural Science Foundation of China(81430029 ; National Natural Science Foundation of China(81430029 ; 2012CB944700) ; 2012CB944700) ; 2012CB944700) ; 2012CB944700) ; 81370951) ; 81370951) ; 81370951) ; 81370951) ; 81490743 ; 81490743 ; 81490743 ; 81490743 ; 31371453 ; 31371453 ; 31371453 ; 31371453 ; 31571548) ; 31571548) ; 31571548) ; 31571548)
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/22332]
专题	合肥物质科学研究院_中科院强磁场科学中心
作者单位	1.Chinese Acad Sci, Inst Zool, Key Lab Anim Ecol & Conservat Biol, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Shandong Univ, Shandong Prov Hosp, Ctr Reprod Med, Jinan 250021, Shandong, Peoples R China 4.Minist Educ, Key Lab Reprod Endocrinol, Jinan 250001, Shandong, Peoples R China 5.Nanjing Agr Univ, Nanjing 210095, Jiangsu, Peoples R China 6.Chinese Acad Sci, Inst Zool, State Key Lab Reprod Biol, Beijing 100101, Peoples R China 7.Chinese Acad Sci, High Magnet Field Lab, Hefei 230031, Anhui, Peoples R China 8.Shanghai Key Lab Assisted Reprod & Reprod Genet, Shanghai 200135, Peoples R China 9.Shanghai Jiao Tong Univ, Ren Ji Hosp, Sch Med, Ctr Reprod Med, Shanghai 200135, Peoples R China
推荐引用方式 GB/T 7714	Yuan, Xiaoxue,Hu, Tao,Zhao, Han,et al. Brown adipose tissue transplantation ameliorates polycystic ovary syndrome[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2016,113(10):2708-2713.
APA	Yuan, Xiaoxue.,Hu, Tao.,Zhao, Han.,Huang, Yuanyuan.,Ye, Rongcai.,...&Chen, Zi-Jiang.(2016).Brown adipose tissue transplantation ameliorates polycystic ovary syndrome.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,113(10),2708-2713.
MLA	Yuan, Xiaoxue,et al."Brown adipose tissue transplantation ameliorates polycystic ovary syndrome".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 113.10(2016):2708-2713.