Iridium-catalyzed asymmetric hydrogenation of cyclic iminium salts | |
Shi, Lei1,3; Ji, Yue1,2; Feng, Guang-Shou1; Chen, Mu-Wang1; Du, Haifeng3; Zhou, Yong-Gui1 | |
刊名 | ORGANIC CHEMISTRY FRONTIERS |
2017-06-01 | |
卷号 | 4期号:6页码:1125-1129 |
英文摘要 | An enantioselective hydrogenation of cyclic iminium salts has been successfully realized by employing [Ir(COD)Cl](2) and chiral diphosphine ligands as catalyst, furnishing chiral N-alkyl tetrahydroisoquinolines and N-alkyl tetrahydro-beta-carbolines with up to 96% ee and 88% ee, respectively. The hydrogenation provides a direct, simple and efficient protocol toward chiral tertiary amines. Meanwhile, asymmetric hydrogenation at the gram scale was also conducted smoothly without loss of reactivity and enantioselectivity. |
WOS标题词 | Science & Technology ; Physical Sciences |
类目[WOS] | Chemistry, Organic |
研究领域[WOS] | Chemistry |
关键词[WOS] | BETA-CARBOLINE ALKALOIDS ; N-H IMINES ; ENANTIOSELECTIVE SYNTHESIS ; HETEROAROMATIC-COMPOUNDS ; PYRIDINIUM SALTS ; PAENIBACILLUS-LACTIS ; (R)-IMINE REDUCTASE ; AQUEOUS-MEDIA ; ANION-BINDING ; TETRAHYDROISOQUINOLINE |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000405862600033 |
内容类型 | 期刊论文 |
源URL | [http://cas-ir.dicp.ac.cn/handle/321008/151911] |
专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China |
推荐引用方式 GB/T 7714 | Shi, Lei,Ji, Yue,Feng, Guang-Shou,et al. Iridium-catalyzed asymmetric hydrogenation of cyclic iminium salts[J]. ORGANIC CHEMISTRY FRONTIERS,2017,4(6):1125-1129. |
APA | Shi, Lei,Ji, Yue,Feng, Guang-Shou,Chen, Mu-Wang,Du, Haifeng,&Zhou, Yong-Gui.(2017).Iridium-catalyzed asymmetric hydrogenation of cyclic iminium salts.ORGANIC CHEMISTRY FRONTIERS,4(6),1125-1129. |
MLA | Shi, Lei,et al."Iridium-catalyzed asymmetric hydrogenation of cyclic iminium salts".ORGANIC CHEMISTRY FRONTIERS 4.6(2017):1125-1129. |
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