Flavonoids from Potentilla parvifolia FISCH and Their Neuroprotective Effects in Human Neuroblastoma SH-SY5Y Cells in vitro

	Flavonoids from Potentilla parvifolia FISCH and Their Neuroprotective Effects in Human Neuroblastoma SH-SY5Y Cells in vitro
	Suo, Yourui 1; Li, Gang 3; Wang, Honglun 1,2; Wang, Zhenhua 3; Luan, Guangxiang 1,4; Li, Ji 3; Yuan, Zhenzhen 1,4; Hao, Xueyan 3
刊名	CHEMISTRY & BIODIVERSITY
	2017-06-01
卷号	14 期号:6
关键词	Potentilla parvifolia FISCH. Flavonoids Neuroprotective effects SH-SY5Y cells Tau phosphorylation
英文摘要	Potentilla parvifolia FISCH. (Rosaceae) is a traditional medicinal plant in P. R. China. In this study, seven flavonoids, ayanin (1), tricin (2), quercetin (3), tiliroside (4), miquelianin (5), isoquercitrin (6), and astragalin (7), were separated and purified from ethyl acetate extractive fractions from ethanol extracts of P. parvifolia using a combination of sevaral chromatographic methods. The human neuroblastoma SH-SY5Y cells were differentiated with all trans-retinoic acid and treated with okadaic acid to induce tau protein phosphorylation and synaptic atrophy, which could establish an Alzheimer's disease cell model. The neuroprotective effects of these flavonoids in cellular were evaluated in vitro by this cell model. Results from the Western blot and morphology analysis suggested that compounds 3 and 4 had the better neuroprotective effects.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]	Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
研究领域[WOS]	Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]	RETINOIC ACID ; INDUCED NEUROTOXICITY ; ALZHEIMERS-DISEASE ; AGRIMONIA-PILOSA ; DIFFERENTIATION ; ACTIVATION ; APOPTOSIS ; TAU ; ANTIOXIDANT ; EXPRESSION
收录类别	SCI
语种	英语
WOS记录号	WOS:000405126900021
内容类型	期刊论文
源URL	[http://ir.nwipb.ac.cn/handle/363003/7075]
专题	西北高原生物研究所_中国科学院西北高原生物研究所
作者单位	1.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Tibetan Med Res, Xining 810008, Peoples R China 2.Qinghai Univ, State Key Lab Plateau Ecol & Agr, Xining 810008, Peoples R China 3.Yantai Univ, Coll Life Sci, Ctr Mitochondria & Hlth Aging, Yantai 264005, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Suo, Yourui,Li, Gang,Wang, Honglun,et al. Flavonoids from Potentilla parvifolia FISCH and Their Neuroprotective Effects in Human Neuroblastoma SH-SY5Y Cells in vitro[J]. CHEMISTRY & BIODIVERSITY,2017,14(6).
APA	Suo, Yourui.,Li, Gang.,Wang, Honglun.,Wang, Zhenhua.,Luan, Guangxiang.,...&Hao, Xueyan.(2017).Flavonoids from Potentilla parvifolia FISCH and Their Neuroprotective Effects in Human Neuroblastoma SH-SY5Y Cells in vitro.CHEMISTRY & BIODIVERSITY,14(6).
MLA	Suo, Yourui,et al."Flavonoids from Potentilla parvifolia FISCH and Their Neuroprotective Effects in Human Neuroblastoma SH-SY5Y Cells in vitro".CHEMISTRY & BIODIVERSITY 14.6(2017).