NB-3 signaling mediates the cross-talk between post-traumatic spinal axons and scar-forming cells | |
Huang, ZH; Gao, YR; Sun, YH; Zhang, C; Yin, Y; Shimoda, Y; Watanabe, K; Liu, YB; Liu, YB (reprint author), Soochow Univ, Jiangsu Key Lab Translat Res & Therapy Neuropsych, Inst Neurosci, Suzhou, Peoples R China. | |
刊名 | EMBO JOURNAL |
2016-08-15 | |
卷号 | 35期号:16页码:1745-1765 |
关键词 | NB-3 axonal regeneration spinal cord injury |
ISSN号 | 0261-4189 |
DOI | 10.15252/embj.201593460 |
文献子类 | Article |
英文摘要 | Little is known about the molecules mediating the cross-talk between post-traumatic axons and scar-forming cells after spinal cord injury. We found that a sustained NB-3 induction was simultaneously present in the terminations of post-traumatic corticospinal axons and scar-forming cells at the spinal lesion site, where they were in direct contact when axons tried to penetrate the glial scar. The regrowth of corticospinal axons was enhanced in vivo with NB-3 deficiency or interruption of NB-3 trans-homophilic interactions. Biochemical, in vitro and in vivo evidence demonstrated that NB-3 homophilically interacted in trans to initiate a growth inhibitory signal transduction from scar-forming cells to neurons by modulating mTOR activity via CHL1 and PTP sigma. NB-3 deficiency promoted BMS scores, electrophysiological transmission, and synapse reformation between regenerative axons and neurons. Our findings demonstrate that NB-3 trans-homophilic interactions mediate the cross-talk between post-traumatic axons and scarforming cells and impair the intrinsic growth ability of injured axons. |
学科主题 | Biochemistry & Molecular Biology ; Cell Biology |
出版地 | HOBOKEN |
资助项目 | 国家自然科学基金项目 ; 国家重点基础研究发展计划以及国家重大科学研究计划(973计划) |
项目编号 | National Natural Sciences Foundation of China [81330026, 31271259, 30990261, 30871425] ; National Key Basic Research Development Program of the Ministry of Science and Technology of China (973 Program) [2013CB945600] ; Chinese Academy of Sciences [KSCX2-EW-Q-11] ; Priority Academic Program Development of Jiangsu Higher Education Institutions |
语种 | 英语 |
WOS记录号 | WOS:000382317500005 |
资助机构 | NSFC ; MOST |
内容类型 | 期刊论文 |
源URL | [http://ir.lzu.edu.cn/handle/262010/178494] |
专题 | 学院待认领_期刊论文 |
通讯作者 | Liu, YB (reprint author), Soochow Univ, Jiangsu Key Lab Translat Res & Therapy Neuropsych, Inst Neurosci, Suzhou, Peoples R China. |
推荐引用方式 GB/T 7714 | Huang, ZH,Gao, YR,Sun, YH,et al. NB-3 signaling mediates the cross-talk between post-traumatic spinal axons and scar-forming cells[J]. EMBO JOURNAL,2016,35(16):1745-1765. |
APA | Huang, ZH.,Gao, YR.,Sun, YH.,Zhang, C.,Yin, Y.,...&Liu, YB .(2016).NB-3 signaling mediates the cross-talk between post-traumatic spinal axons and scar-forming cells.EMBO JOURNAL,35(16),1745-1765. |
MLA | Huang, ZH,et al."NB-3 signaling mediates the cross-talk between post-traumatic spinal axons and scar-forming cells".EMBO JOURNAL 35.16(2016):1745-1765. |
个性服务 |
查看访问统计 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论