Effect of combined drospirenone with estradiol for hypertensive postmenopausal women: a systemic review and meta-analysis

doi:10.1080/09513590.2016.1183629

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	Effect of combined drospirenone with estradiol for hypertensive postmenopausal women: a systemic review and meta-analysis
	Zhao, X; Zhang, XF; Zhao, Y; Lin, X; Li, NY; Paudel, G; Wang, QY; Zhang, XW; Li, XL; Yu, J
刊名	GYNECOLOGICAL ENDOCRINOLOGY
	2016
卷号	32 期号:9 页码:685-689
关键词	Drospirenone estrogen hypertension meta-analysis postmenopausal
ISSN号	0951-3590
DOI	10.1080/09513590.2016.1183629
文献子类	Review
英文摘要	Postmenopausal hypertensive is associated with estrogen deficiency. This meta-analysis was performed to assess the efficacy and safety of drospirenone combined with 17-beta-estradiol (DRSP/E2) in postmenopausal hypertensive women. A systemic literature search of PubMed, Embase, Cochrane Library, Web of Science (up to Oct. 2015) was performed. Studies were screened independently by two researchers according to the inclusion and exclusion criteria which included only the randomized controlled trials (RCT) about the drospirenone with 17-beta-estradiol for postmenopausal women with hypertension. The methodological quality was evaluated by Cochrane handbook 5.1.0 and meta-analysis was conducted using RevMan 5.3.0 software. Five randomized controlled trials involved 1121 patients who met the eligibility criteria. Overall, DRSP/E2 group was superior in reducing clinical blood pressure (BP) and 24-h mean BP. There was no significant change in potassium levels on DRSP/E2 group versus control group, suggesting probability potassium sparing effect of this hormone therapy. The incidences of adverse events were low and similar. The current evidences indicate that DRSP 3 mg/E2 2mg can significantly lower both systolic and diastolic blood pressure in postmenopausal hypertensive women.
学科主题	Endocrinology & Metabolism ; Obstetrics & Gynecology
出版地	ABINGDON
资助项目	国家自然科学基金项目 ; 甘肃省技术研究与开发专项计划
项目编号	National Natural Science Foundation of China [NSFC-81270332] ; Gansu Province Natural Science Foundation [1104FKCA150, 1205TCYA042] ; Gansu Administration of Traditional Medicine Foundation [GZK-2010-Z-1]
语种	英语
WOS记录号	WOS:000388797600001
资助机构	NSFC ; GSSTD
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/188707]
专题	第二临床医学院_期刊论文
通讯作者	Yu, J (reprint author), Lanzhou Univ, Hosp 2, Dept Hypertens, 82 Cuiyingmen St, Lanzhou 730030, Peoples R China.
推荐引用方式 GB/T 7714	Zhao, X,Zhang, XF,Zhao, Y,et al. Effect of combined drospirenone with estradiol for hypertensive postmenopausal women: a systemic review and meta-analysis[J]. GYNECOLOGICAL ENDOCRINOLOGY,2016,32(9):685-689.
APA	Zhao, X.,Zhang, XF.,Zhao, Y.,Lin, X.,Li, NY.,...&Yu, J .(2016).Effect of combined drospirenone with estradiol for hypertensive postmenopausal women: a systemic review and meta-analysis.GYNECOLOGICAL ENDOCRINOLOGY,32(9),685-689.
MLA	Zhao, X,et al."Effect of combined drospirenone with estradiol for hypertensive postmenopausal women: a systemic review and meta-analysis".GYNECOLOGICAL ENDOCRINOLOGY 32.9(2016):685-689.