The Endothelial Nitric Oxide Synthase Gene T-786C Polymorphism Increases Myocardial Infarction Risk: A Meta-Analysis

doi:10.12659/MSM.899905

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	The Endothelial Nitric Oxide Synthase Gene T-786C Polymorphism Increases Myocardial Infarction Risk: A Meta-Analysis
	Kong, XZ; Zhang, ZY; Wei, LH; Li, R; Yu, J; Yu, J (reprint author), Lanzhou Univ, Hosp 2, Dept Hypertens, Lanzhou, Gansu, Peoples R China.
刊名	MEDICAL SCIENCE MONITOR
	2017-02-11
卷号	23 页码:759-766
关键词	Myocardial Infarction Nitric Oxide Synthase Type III Polymorphism, Single Nucleotide
ISSN号	1643-3750
DOI	10.12659/MSM.899905
文献子类	Article
英文摘要	Background: Polymorphisms of the endothelial nitric oxide synthase (eNOS) gene are reportedly associated with myocardial infarction (MI) risk. However, definitive evidence of this association is lacking. In this study, we investigated the potential association of eNOS gene polymorphisms with MI risk by conducting a meta-analysis of studies evaluating this association. Material/Methods: PubMed, Web of Knowledge, ScienceDirect, China National Knowledge Infrastructure (CNKI), WanFang, and Database of Chinese Scientific and Technical Periodicals (VIP) were searched for relevant studies. Pooled odds ratios (OR) with 95% confidence interval (CI) were calculated to evaluate the association of eNOS gene T-786C and 4b4a polymorphisms with MI risk. Results: Fifteen studies with 8,067 controls and 4,923 MI cases were included in the final meta-analysis. In the overall analysis, T-786C (rs2070744) polymorphism was associated with MI risk (p<0.05, OR=1.69, 95% CI: 1.53-1.86 for T vs. C; p<0.05, OR=2.76, 95% CI: 2.03-3.75 for TT vs. CC; p<0.05, OR=1.74, 95% CI 1.56-1.95 for TT vs. (CT + CC); p<0.05, OR=2.43, 95% CI: 1.79-3.30 for (CT + TT) vs. CC). In addition, a significant association between 4b4a VNTR polymorphism and MI risk was observed. On sub-group analyses by ethnicity, a significant increase in MI risk was observed separately for Asian and Caucasian populations for T-786C polymorphism, but not for the 4b4a polymorphism. Conclusions: In this meta-analysis, T-786C polymorphism of the eNOS gene was associated with the risk of MI, especially in the Asian populations.
学科主题	Research & Experimental Medicine
出版地	SMITHTOWN
资助项目	兰州市科技局资助项目
项目编号	Lanzhou City Science and Technology Development Projects Foundation [2012-1-31]
语种	英语
WOS记录号	WOS:000393886300001
资助机构	LZSTB
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/188689]
专题	第二临床医学院_期刊论文
通讯作者	Yu, J (reprint author), Lanzhou Univ, Hosp 2, Dept Hypertens, Lanzhou, Gansu, Peoples R China.
推荐引用方式 GB/T 7714	Kong, XZ,Zhang, ZY,Wei, LH,et al. The Endothelial Nitric Oxide Synthase Gene T-786C Polymorphism Increases Myocardial Infarction Risk: A Meta-Analysis[J]. MEDICAL SCIENCE MONITOR,2017,23:759-766.
APA	Kong, XZ,Zhang, ZY,Wei, LH,Li, R,Yu, J,&Yu, J .(2017).The Endothelial Nitric Oxide Synthase Gene T-786C Polymorphism Increases Myocardial Infarction Risk: A Meta-Analysis.MEDICAL SCIENCE MONITOR,23,759-766.
MLA	Kong, XZ,et al."The Endothelial Nitric Oxide Synthase Gene T-786C Polymorphism Increases Myocardial Infarction Risk: A Meta-Analysis".MEDICAL SCIENCE MONITOR 23(2017):759-766.