Electroclinical aspects and therapy of Han patients with juvenile myoclonic epilepsy in northern China

doi:10.1016/j.yebeh.2016.07.011

CORC > 兰州大学 > 兰州大学 > 第二临床医学院 > 期刊论文

	Electroclinical aspects and therapy of Han patients with juvenile myoclonic epilepsy in northern China
	Wang, L; Jiang, Z; Chen, BB; Wang, CT; Wang, JX; Bai, J; Wang, B; Jin, L; Zhang, WJ; Deng, YC
刊名	EPILEPSY & BEHAVIOR
	2016-09
卷号	62 页码:204-208
关键词	Electroclinical characteristics Photoparoxysmal responses Generalized spike-wave discharge Valproate
ISSN号	1525-5050
DOI	10.1016/j.yebeh.2016.07.011
文献子类	Article
英文摘要	Objective: The objective of this study was to assess the electroclinical aspects and treatment of Han patients with juvenile myoclonic epilepsy (JME) in northern China. Methods: One hundred fifty-six outpatients with JME from six epilepsy centers, between January 2011 and June 2012, were followed up for at least two years. They underwent twenty-four-hour video-EEG recording. Brain imaging was performed using magnetic resonance imaging (MRI). Clinical aspects, electroencephalographic (EEG) features, and antiepileptic drugs (AEDs) received were reviewed. Results: Generalized tonic-clonic seizures (GTCS) were found in 150/156 patients. Delay of diagnosis was 4.60 +/- 9.92 years. Photosensitivity was more common in eye closure condition during IPS in patients with JME; in addition, patients with JME with myoclonic seizures (MS) and GTCS as seizure types were likely to present photoparoxysmal responses (PPRs). The 82 nontreated patients showed a median latency to first interictal or ictal generalized spike-wave discharge (GSWD) of 50 min (IQR: 22-102 min). The first GSWDs were recorded in 63%, 76%, 90%, and 98% patients within one, two, three, and 4 h, respectively; only 2% of patients had first GSWDs after 4 h. One hundred eleven patients (111/156) chose extended-release valproate (VPA) at daily doses <= 1000 mg. The percentages of seizure-free patients among MS, GTCS, and absence seizure (AS) groups were 88.3%, 99.0%, and 94.9%, respectively. Conclusion: Photoparoxysmal responses were more common in patients with JME with MS and GTCS and rare in patients with JME with MS and AS in northern Chinese Han patients. Most patients with JME in northern China chose VPA as first therapeutic choice, and low dose (500 to 1000 mg daily) of extended-release VPA may be an optimal choice for them. Video-EEG monitoring for at least 4 h may be helpful in detecting the first interictal or ictal GSWD in patients with potential JME. Moreover, video-EEG monitoring performed at about 9 o'clock in the morning with patients in the awake state might be useful to find the first GSWD. For JME diagnosis, Class II criteria are more helpful than Class I counterparts, the latter yielding more missed diagnoses. (C) 2016 Elsevier Inc. All rights reserved.
学科主题	Behavioral Sciences ; Neurosciences & Neurology ; Psychiatry
出版地	SAN DIEGO
资助项目	国家自然科学基金项目
项目编号	National Natural Science Foundation of China [31401176] ; Shaanxi Social Development Project [S2011SF1250]
语种	英语
WOS记录号	WOS:000384392500036
资助机构	NSFC
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/188683]
专题	第二临床医学院_期刊论文
通讯作者	Liu, YH (reprint author), Fourth Mil Med Univ, Xijing Hosp, Dept Neurol, 127 West ChangLe Rd, Xian 710032, Peoples R China.
推荐引用方式 GB/T 7714	Wang, L,Jiang, Z,Chen, BB,et al. Electroclinical aspects and therapy of Han patients with juvenile myoclonic epilepsy in northern China[J]. EPILEPSY & BEHAVIOR,2016,62:204-208.
APA	Wang, L.,Jiang, Z.,Chen, BB.,Wang, CT.,Wang, JX.,...&Liu, YH .(2016).Electroclinical aspects and therapy of Han patients with juvenile myoclonic epilepsy in northern China.EPILEPSY & BEHAVIOR,62,204-208.
MLA	Wang, L,et al."Electroclinical aspects and therapy of Han patients with juvenile myoclonic epilepsy in northern China".EPILEPSY & BEHAVIOR 62(2016):204-208.