Regional homogeneity changes in early and advanced Parkinson's disease: a resting state functional magnetic resonance imaging study

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	Regional homogeneity changes in early and advanced Parkinson's disease: a resting state functional magnetic resonance imaging study
	Zhang, J; Hu, WD; Liu, GY; Wu, C; Gan, TJ; Hu, WD (reprint author), Peoples Hosp Gansu Prov, Dept Respirat, 204 Donggang West Rd, Lanzhou 730000, Peoples R China.
刊名	INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
	2016
卷号	9 期号:8 页码:15634-15644
关键词	Parkinson's disease regional homogeneity resting state functional magnetic resonance imaging
ISSN号	1940-5901
文献子类	Article
英文摘要	Objective: Previous work has shown regional homogeneity (ReHo) differences in Parkinson's disease (PD) patients. So looking in more detail at differences between early and late stages is valuable. The aim of our study was to investigate brain activity of early and advanced PD in the resting state by using a ReHo approach. Methods: Functional magnetic resonance images were acquired in 35 patients with PD at in early stage and advanced stage, as well as in 17 age-and sex-matched normal controls (NC). Results: In PD patients compared with NC, we observed decreased ReHo in motor cortex and increased ReHo in the right cuneus and frontal eye field. In early stage of PD, decreased ReHo was located in bilateral posterior insular cortex, dorsolateral prefrontal cortex, angular gyrus, supramarginal gyrus, left precuneus, right superior temporal gyrus, and right cerebellar posterior lobe, in addition to motor cortex; and increased ReHo in the left cerebellar anterior lobe. During disease evolution, decreased ReHo was found in more brain areas, including right cerebellar posterior lobe, bilateral orbitofrontal cortex, gyrus rectus and left middle and inferior temporal gyrus; and increased ReHo in bilateral middle occipital gyrus, insular cortex, cingulate gyrus, superior temporal gyrus, and right middle temporal gyrus and thalamus. Whereas no changes were observed in bilateral motor cortex. Conclusion: Our results indicate that neuronal activity decrease in motor cortex with no marked variation during disease progression in a resting state, and decreased cognitive function may be associated with worsening motor symptoms in PD.
学科主题	Research & Experimental Medicine
出版地	MADISON
资助项目	甘肃省自然科学基金计划
项目编号	Natural Science Foundation from the Science and Technology Office of Gansu Province in China [1010RJZA096]
语种	英语
WOS记录号	WOS:000385837700071
资助机构	GSSTD
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/188672]
专题	第二临床医学院_期刊论文
通讯作者	Hu, WD (reprint author), Peoples Hosp Gansu Prov, Dept Respirat, 204 Donggang West Rd, Lanzhou 730000, Peoples R China.
推荐引用方式 GB/T 7714	Zhang, J,Hu, WD,Liu, GY,et al. Regional homogeneity changes in early and advanced Parkinson's disease: a resting state functional magnetic resonance imaging study[J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,2016,9(8):15634-15644.
APA	Zhang, J,Hu, WD,Liu, GY,Wu, C,Gan, TJ,&Hu, WD .(2016).Regional homogeneity changes in early and advanced Parkinson's disease: a resting state functional magnetic resonance imaging study.INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,9(8),15634-15644.
MLA	Zhang, J,et al."Regional homogeneity changes in early and advanced Parkinson's disease: a resting state functional magnetic resonance imaging study".INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE 9.8(2016):15634-15644.